Atrial fibrillation and inflammation

Table 3 Corticosteroids and atrial fibrillation

Ref.	Study design	Subjects	Conclusion
Chaney et al[57]	Prospective	60 patients undergoing CABG surgery; methylprednisolone	No effects of steroids on in the incidence of AF
Yared et al[58]	Randomized	235 patients undergoing CABG or valve surgery	Dexamethasone decreased incidence of new-onset AF
Yared et al[59]	Randomized	78 patients undergoing CABG or valve surgery	Dexamethasone did not decrease incidence of new-onset AF and inflammation
Dernellis et al[17]	Randomized	104 patients undergoing electrical cardioversion	Methylprednisolone decreased plasma CRP levels and AF recurrence
Goldstein et al[61]	Animal study	Canine sterile pericarditis model	Prednisone treatment decreased inflammation, and eliminated atrial arrhythmia inducibility
Halonen et al[60]	Randomized	241 patients undergoing CABG or valve surgery	Corticosteroids decreased the incidence of postoperative AF and serum CRP levels
Baker et al[62]	Meta-analysis	Nine studies with 990 patients undergoing CABG or valve surgery	Positive effects of perioperative corticosteroid use on AF occurrence

AF: Atrial fibrillation; CABG: Coronary artery bypass grafting; CRP: C-reactive protein.