Coronary microvascular dysfunction in diabetes mellitus: A review

Figure 2 Possible mechanisms involved in vasomotion of impaired coronary arterioles in diabetes. Several mechanisms have been postulated to be responsible for impaired vasomotion in coronary artery disease. There is strong evidence accumulating in favor of each impairment category as causal. We hypothesize that they interact in as yet unspecified ways rather than operate through separate pathways to cause diabetes. Major challenges in this field include better understanding each of these mechanisms, but the greatest opportunity for seminal breakthroughs may reside in reconciling our understanding among these mechanisms and their roles in diabetes.