Ivabradine in the treatment of congenital junctional ectopic tachycardia: A systematic review

Table 3 Summary of the main findings of included studies

Ref.	Antiarrhythmic medication before ivabradine	Treatment with ivabradine (Dose)	Antiarrhythmic medication with ivabradine	Outcomes of treatment with ivabradine	Adverse effects following ivabradine administration	Recurrence
Upreti et al[16]	Adenosine, amiodarone	0.1 mg/kg/dose twice a day	Amiodorane, monotherapy at discharge	SR, HR control	None	_
Devaprasath et al[9]	Adenosine	0.1 mg/kg/dose twice a day	None	SR, HR control, JR intermittent	None	Not noticed within 2 weeks of follow up
Asfour et al[10]	Propranolol, amiodarone	0.05 mg/kg/dose twice a day, decreased to 0.04 mg/kg/dose twice a day, at discharge 008 mg/kg/d	Propranolol, amiodorane; monotherapy at 2nd week	SR, HR control	Bradycardia prior to monotherapy	Not noticed within 6 months of follow up
Di Marco et al[8]	Amiodarone, flecainide, propranolol	0.25 mg/kg/day (with propranolol, amydarone), 0.3 mg/kg/day (with flecainide)	Propranolol, amiodorane, flecainide	HR control, SR (with flecainide)	None	_
Ríos et al[17]	Amiodarone, propranolol, n = 2; flecainide, n = 1	0.05 mg/kg/dose, at discharge 0.1 mg/kg/day	Amiodorane, propranolol (discontinued later)	SR/JR, HR control	None	_
Michel et al[15]	Adenosine, Flecainide, Amiodarone, Esmolol	0.025 mg/kg/dose twice a day, increased to 0.05 mg/kg/dose	Esmolol (discontinued later), metprolol	HR control, SR/EAR	None	_
Kothari et al[13]	Amiodarone, flecainide, n = 2; propranolol, enalapril, metoprolol, n = 1	0.05 mg/kg/dose twice a day	Amiodarone, flecainide, n = 2; propranolol, enalapril, metaprolol, n = 1	SR, HR control	None	_
Ergul et al[18]	Flecainide, amiodarone, digoxin, n = 1; Flecainide, amiodarone, propranolol, n = 2	0.1 mg/kg/day	Amiodarone, n = 1; Amiodarone, propranolol, flecainide, n = 2	HR control, n = 3; SR control, n = 2; JR/SR control, n = 1	None	_
Dieks et al[7]	Amiodarone, n = 5; flecainide, n = 1; digoxin, n = 2	0.05-0.1 mg/kg/dose increased to 0.28 mg/kg/dose	Amidarone, n = 5; propranolol, amidarone, n = 2; digoxin, amiodarone, n = 1	HR control, n = 5; SR, n = 2; JR/JET, n = 1; JR/SR, n = 1	None	_
Alghamdi et al[21]	Flecainide, sotalol, procainamide, amiodarone	2.5 mg once daily	None	SR, HR control	None	_

JR: Junctional rhythm; SR: Sinus rhythm; HR: Heart rate; JET: Junctional ectopic tachycardia; EAR: Ectopic atrial rhythm.