Contemporary nationwide trends in major adverse cardiovascular events in young cannabis users without concomitant tobacco, alcohol, cocaine use

Table 1 Baseline characteristics of young adults hospitalized with cannabis use disorder in absence of concomitant tobacco/cocaine/alcohol use disorder (2016-2019)

		2016	2017	2018	2019	Overall	P value
Age at admission, median (interquartile range)		28 (23, 44)	28 (23, 44)	28 (23, 44)	28 (23, 44)	28 (23, 44)	< 0.001
Sex	Male	58.3	57.2	56.2	55.5	56.8	< 0.001
	Female	41.7	42.8	43.8	44.5	43.2
Race	White	55.1	53.8	53.6	53.6	54.0	< 0.001
	Black	30.8	31.1	30.9	30.8	30.9
	Hispanic	11.8	12.7	13.1	13.2	12.7
	Asian/PI	1.1	1.3	1.3	1.3	1.3
	Native American	1.2	1.0	1.1	1.1	1.1
Median household income national quartile for patient ZIP code	0-25th	40.3	39.8	39.6	40.2	40.0	< 0.001
	26th-50th	25.1	26.5	27.1	25.6	26.1
	51th-75th	20.9	20.2	20.1	20.9	20.5
	76th-100th	13.7	13.5	13.2	13.3	13.4
Payer type	Medicare	9.4	9.0	8.9	8.4	8.9	< 0.001
	Medicaid	50.6	51.9	51.6	50.6	51.2
	Private	26.0	25.5	25.2	25.8	25.6
	Self-pay	13.0	12.7	13.4	14.1	13.3
	No charge	1.0	1.0	0.9	1.0	1.0
Hospital location and teaching status	Rural	8.1	8.0	7.8	7.7	7.9	< 0.001
	Urban nonteaching	24.0	20.6	18.7	16.3	19.8
	Urban teaching	67.9	71.5	73.5	75.9	72.3
Hospital region	Northeast	18.6	18.7	18.6	17.6	18.4	< 0.001
	Midwest	25.1	25.4	24.6	24.6	24.9
	South	34.3	33.4	34.3	36.0	34.5
	West	22.1	22.5	22.5	21.8	22.2
Comorbidities
Hypertension		15.7	15.9	16.2	16.3	16.0	< 0.001
Diabetes		7.4	8.0	7.9	8.2	7.9	< 0.001
Hyperlipidemia		4.5	4.7	4.8	5.1	4.8	< 0.001
Obesity		9.0	9.7	10.0	10.6	9.8	< 0.001
Peripheral vascular disease		0.7	0.7	0.7	0.8	0.7	< 0.001
Prior MI		0.8	0.8	0.8	0.8	0.8	0.187
Prio stroke/transient ischemic attack		0.9	0.9	1.0	0.9	0.9	0.004
Chronic pulmonary disease		12.7	13.1	12.8	12.9	12.9	< 0.001
Hypothyroidism		2.4	2.3	2.3	2.5	2.4	0.001
Other thyroid disorders		0.6	0.7	0.7	0.8	0.7	< 0.001
Valvular heart disease		0.3	0.3	0.3	0.3	0.3	0.054
Cancer		1.0	1.0	1.0	1.0	1.0	0.147

P < 0.05 indicate statistical significance. MI: Myocardial infarction.