Tissue-source effect on mesenchymal stem cells as living biodrugs for heart failure: Systematic review and meta-analysis

doi:10.4330/wjc.v16.i8.469

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Aug 26, 2024 (publication date) through Nov 6, 2024

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World Journal of Cardiology

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1949-8462

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World J Cardiol. Aug 26, 2024; 16(8): 469-483
Published online Aug 26, 2024. doi: 10.4330/wjc.v16.i8.469

Table 4 Intervention characteristics of randomized controlled trials of umbilical-cord-derived mesenchymal stem cells

Refs	Cell type	Cell condition	MSCs dose and volume	Route of delivery	Concurrent procedure (if any)
He et al[18]	WJUC-MSCs	Frozen	1 × 10⁸/1.5-2.5 mL +/- 1 mL collagen scaffold	IM	CABG for all groups
Zhao et al[26]	UC-MSCs	N/S	N/S	IC	N/A
Bartolucci et al[28]	WJUC-MSCs	Frozen	1 × 10⁶/kg in 100 mL	IV	N/A
Ulus et al[25]	UC-MSCs	Frozen	23 × 10⁶	IM	CABG for all groups
Gao et al[21]	WJUC- MSCs	Fresh	6 × 10⁶	IC	N/A

CABG: Coronary artery bypass grafting; N/A: Not available; N/S: Not specified; IC: Intracoronary; IM: Intramyocardial; IV: Intravenous; PCI: Percutaneous coronary intervention; WJUC-MSCs: Wharton’s Jelly umbilical cord mesenchymal stem cells; UC-MSCs: Umbilical cord-derived mesenchymal stem cells; MSCs: Mesenchymal stem cells.

Citation: Safwan M, Bourgleh MS, Aldoush M, Haider KH. Tissue-source effect on mesenchymal stem cells as living biodrugs for heart failure: Systematic review and meta-analysis. World J Cardiol 2024; 16(8): 469-483
URL: https://www.wjgnet.com/1949-8462/full/v16/i8/469.htm
DOI: https://dx.doi.org/10.4330/wjc.v16.i8.469