Nomogram predicting the cardiovascular disease mortality for older patients with colorectal cancer: A real-world population-based study

Table 2 Competing risk analysis on the cancer-specific mortality and cardiovascular mortality

Variables	Univariate analysis (cancer-specific mortality)			Univariate analysis (CVD-specific mortality)			Multivariate analysis (cancer-specific mortality)			Multivariate analysis (CVD-specific mortality)
	HR	95%CI	P value	HR	95%CI	P value	HR	95%CI	P value	HR	95%CI	P value
Age at diagnosis (years)
60-69	Reference			Reference			Reference			Reference
70-79	1.17	1.14-1.2	< 0.001	2.52	2.36-2.69	< 0.001	1.34	1.3-1.37	< 0.001	2.44	2.29-2.61	< 0.001
≥ 80	1.63	1.58-1.67	< 0.001	7.31	6.88-7.77	< 0.001	1.94	1.88-2	< 0.001	6.43	6.02-6.85	< 0.001
Sex
Female	Reference						Reference			Reference
Male	1.03	1.1-1.05	< 0.01	1.07	1.02-1.11	< 0.01	1.16	1.13-1.19	< 0.001	1.58	1.51-1.65	< 0.001
Marital status
Single	Reference			Reference			Reference			Reference
Married	0.77	0.74-0.80	< 0.001	0.72	0.67-0.77	< 0.001	0.83	0.80-0.86	< 0.001	0.68	0.63-0.73	< 0.001
Others	0.98	0.94-1.02	0.31	1.28	1.19-1.38	< 0.001	0.98	0.94-1.01	0.21	0.93	0.87-1.00	0.06
Race
Black	Reference			Reference			Reference			Reference
White	0.82	0.79-0.85	< 0.001	1.05	0.98-1.12	0.2	0.84	0.81-0.88	< 0.001	0.89	0.83-0.96	< 0.001
Others	0.71	0.68-0.75	< 0.001	0.66	0.50-0.74	< 0.001	0.73	0.69-0.77	< 0.001	0.63	0.57-0.71	< 0.001
Year of diagnosis
2004-2007	Reference			Reference			Reference			Reference
2008-2011	0.92	0.9-0.95	< 0.001	0.86	0.82-0.91	< 0.001	0.89	0.87-0.91	< 0.001	0.89	0.85-0.94	< 0.001
2012-2015	0.85	0.83-0.88	< 0.001	0.73	0.68-0.78	< 0.001	0.82	0.8-0.85	< 0.001	0.79	0.74-0.85	< 0.001
Primary site
Right half colon	Reference			Reference			Reference			Reference
Left half colon	0.93	0.9-0.95	< 0.001	0.84	0.80-0.89	< 0.001	0.99	0.96-1.02	0.39	1.02	0.97-1.07	0.44
Rectum	1.07	1.04-1.1	< 0.001	0.76	0.72-0.80	< 0.001	1.08	1.04-1.12	< 0.001	1.06	0.99-1.13	0.08
TNM stage
I	Reference			Reference			Reference			Reference
II	2.09	1.99-2.19	< 0.001	1.05	1.00-1.11	0.05	1.39	1.29-1.49	< 0.001	1.03	0.98-1.09	0.26
III	4.39	4.19-4.59	< 0.001	0.86	0.81-0.90	< 0.001	2.46	2.28-2.65	< 0.001	0.78	0.63-0.98	0.04
IV	18.42	17.61-19.27	< 0.001	0.73	0.65-0.81	< 0.001	9.26	8.61-9.95	< 0.001	0.87	0.72-1.06	0.17
Grade
Well	Reference			Reference			Reference			Reference
Moderate	1.64	1.56-1.72	< 0.001	1.05	0.98-1.13	0.14	1.26	1.2-1.33	< 0.001	1.05	0.99-1.13	0.15
Poorly	3.11	2.95-3.28	< 0.001	1.14	1.05-1.24	< 0.001	1.65	1.56-1.74	< 0.001	1.08	0.98-1.13	0.07
Undifferentiated	3.48	3.22-3.76	< 0.001	1.11	0.93-1.31	0.25	1.81	1.68-1.96	< 0.001	1.11	0.93-1.32	0.26
Histology
Adenocarcinoma	Reference			Reference			Reference			Reference
Mucinous adenocarcinoma and signet-ring cell carcinoma	1.26	1.21-1.31	< 0.001	1.14	1.06-1.23	< 0.001	1.05	1.01-1.09	0.01	1.13	1.05-1.22	< 0.01
Others	0.71	0.68-0.74	< 0.001	1	0.94-1.06	0.95	1.01	0.97-1.04	0.77	1.01	0.95-1.07	0.77
Surgery
Yes	Reference			Reference			Reference			Reference
No	4.24	4.09-4.4	< 0.001	1.74	1.57-1.94	< 0.001	3.46	3.32-3.62	< 0.001	2.07	1.86-2.32	< 0.001
Radiotherapy
Yes	Reference			Reference			Reference			Reference
No	1.22	1.18-1.26	< 0.001	0.57	0.52-0.61	< 0.001	1.17	1.12-1.22	< 0.001	0.99	0.89-1.10	0.9
Chemotherapy
Yes	Reference			Reference			Reference			Reference
No	1.66	1.62-1.7	< 0.001	0.39	0.37-0.41	< 0.001	1.66	1.64-1.68	< 0.001	0.51	0.47-0.55	< 0.001

CVD: Cardiovascular disease.