Network pharmacology-based exploration of molecular mechanisms underlying therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure with spleen Qi deficiency syndrome

Table 1 Active ingredients of herbs composing Jianpi Huatan Quyu recipe

Molecule ID	Molecule name	Drug(s)	Molecule ID	Molecule name	Drug(s)
MOL007059	3-β-hydroxymethyllenetanshiquinone	Danshen, Dangshen	MOL001792	DFV	Gancao
MOL004355	Spinasterol	Dangshen, Gualou	MOL001484	Inermine	Gancao
MOL003896	7-methoxy-2-methyl isoflavone	Dangshen, Gancao	MOL000500	Vestitol	Gancao
MOL002776	Baicalin	Banxia, Danshen	MOL000497	Licochalcone a	Gancao
MOL000449	Stigmasterol	Banxia, Dangshen	MOL000359	Sitosterol	Gancao
MOL000422	Kaempferol	Gancao, Huangqi	MOL000300	Dehydroeburicoic acid	Fuling
MOL000417	Calycosin	Gancao, Huangqi	MOL000292	Poricoic acid C	Fuling
MOL000392	Formononetin	Gancao, Huangqi	MOL000291	Poricoic acid B	Fuling
MOL000354	Isorhamnetin	Gancao, Huangqi	MOL000290	Poricoic acid A	Fuling
MOL000296	Hederagenin	Fuling, Huangqi	MOL000289	Pachymic acid	Fuling
MOL000239	Jaranol	Gancao, Huangqi	MOL000287	3-β-hydroxy-24-methylene-8-lanostene-21-oic acid	Fuling
MOL000211	Mairin	Gancao, Huangqi	MOL000285	(2R)-2-[(5R,10S,13R,14R,16R,17R)-16-hydroxy-3-keto-4,4,10,13,14-pentamethyl-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-17-yl]-5-isopropyl-hex-5-enoic acid	Fuling
MOL000098	Quercetin	Gancao, Huangqi	MOL000283	Ergosterol peroxide	Fuling
MOL000033	(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R,5S)-5-propan-2-yloctan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol	Baizhu, Huangqi	MOL000282	Ergosta-7,22E-dien-3beta-ol	Fuling
MOL000006	Luteolin	Danshen, Dangshen	MOL000280	(2R)-2-[(3S,5R,10S,13R,14R,16R,17R)-3,16-dihydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-5-isopropyl-hex-5-enoic acid	Fuling
MOL000442	1,7-dihydroxy-3,9-dimethoxy pterocarpene	Huangqi	MOL000279	Cerevisterol	Fuling
MOL000439	Isomucronulatol-7,2'-di-O-glucosiole	Huangqi	MOL000276	7,9(11)-Dehydropachymic acid	Fuling
MOL000438	(3R)-3-(2-hydroxy-3,4-dimethoxyphenyl)chroman-7-ol	Huangqi	MOL000275	Trametenolic acid	Fuling
MOL000433	FA	Huangqi	MOL000273	(2R)-2-[(3S,5R,10S,13R,14R,16R,17R)-3,16-dihydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-enoic acid	Fuling
MOL000398	Isoflavanone	Huangqi	MOL008411	11-Hydroxyrankinidine	Dangshen
MOL000387	Bifendate	Huangqi	MOL008407	(8S,9S,10R,13R,14S,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-1,2,4,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one	Dangshen
MOL000380	(6aR,11aR)-9,10-dimethoxy-6a,11a-dihydro-6H-benzofurano[3,2-c]chromen-3-ol	Huangqi	MOL008406	Spinoside A	Dangshen
MOL000379	9,10-dimethoxypterocarpan-3-O-β-D-glucoside	Huangqi	MOL008400	Glycitein	Dangshen
MOL000378	7-O-methylisomucronulatol	Huangqi	MOL008397	Daturilin	Dangshen
MOL000374	5'-hydroxyiso-muronulatol-2',5'-di-O-glucoside	Huangqi	MOL008393	7-(β-xylosyl)cephalomannine_qt	Dangshen
MOL000371	3,9-di-O-methylnissolin	Huangqi	MOL008391	5α-Stigmastan-3,6-dione	Dangshen
MOL007180	Vitamin E	Gualou	MOL007514	Methyl icosa-11,14-dienoate	Dangshen
MOL007179	Linolenic acid ethyl ester	Gualou	MOL006774	Stigmast-7-enol	Dangshen
MOL007175	Karounidiol 3-O-benzoate	Gualou	MOL006554	Taraxerol	Dangshen
MOL007172	7-oxo-Dihydrokaro-unidiol	Gualou	MOL005321	Frutinone A	Dangshen
MOL007171	5-Dehydrokarounidiol	Gualou	MOL004492	Chrysanthemaxanthin	Dangshen
MOL007165	10α-cucurbita-5,24-diene-3β-ol	Gualou	MOL003036	ZINC03978781	Dangshen
MOL006756	Schottenol	Gualou	MOL002879	Diop	Dangshen
MOL005530	hydroxygenkwanin	Gualou	MOL002140	Perlolyrine	Dangshen
MOL002881	Diosmetin	Gualou	MOL001006	Poriferasta-7,22E-dien-3β-ol	Dangshen
MOL001494	Mandenol	Gualou	MOL007156	Tanshinone Ⅵ	Danshen
MOL005020	Dehydroglyasperins C	Gancao	MOL007155	(6S)-6-(hydroxymethyl)-1,6-Dimethyl-8,9-dihydro-7H-naphtho[8,7-g]benzofuran-10,11-dione	Danshen
MOL005018	Xambioona	Gancao	MOL007154	Tanshinone iia	Danshen
MOL005017	Phaseol	Gancao	MOL007152	Przewaquinone E	Danshen
MOL005016	Odoratin	Gancao	MOL007151	Tanshindiol B	Danshen
MOL005013	18α-hydroxyglycyrrhetic acid	Gancao	MOL007150	(6S)-6-hydroxy-1-methyl-6-methylol-8,9-dihydro-7H-naphtho[8,7-g]benzofuran-10,11-quinone	Danshen
MOL005012	Licoagroisoflavone	Gancao	MOL007149	NSC 122421	Danshen
MOL005008	Glycyrrhiza flavonol A	Gancao	MOL007145	Salviolone	Danshen
MOL005007	Glyasperins M	Gancao	MOL007143	Salvilenone I	Danshen
MOL005003	Licoagrocarpin	Gancao	MOL007142	Salvianolic acid J	Danshen
MOL005001	Gancaonin H	Gancao	MOL007141	Salvianolic acid G	Danshen
MOL005000	Gancaonin G	Gancao	MOL007140	(Z)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)vinyl]-3,4-dihydroxy-phenyl]acrylic acid	Danshen
MOL004996	Gadelaidic acid	Gancao	MOL007132	(2R)-3-(3,4-dihydroxyphenyl)-2-[(Z)-3-(3,4-dihydroxyphenyl)acryloyl]oxy-propionic acid	Danshen
MOL004993	8-prenylated eriodictyol	Gancao	MOL007130	Prolithospermic acid	Danshen
MOL004991	7-acetoxy-2-methylisoflavone	Gancao	MOL007127	1-methyl-8,9-dihydro-7H-naphtho[5,6-g]benzofuran-6,10,11-trione	Danshen
MOL004990	7,2',4'-trihydroxy-5-methoxy-3-arylcoumarin	Gancao	MOL007125	Neocryptotanshinone	Danshen
MOL004989	6-prenylated eriodictyol	Gancao	MOL007124	Neocryptotanshinone II	Danshen
MOL004988	Kanzonol F	Gancao	MOL007123	Miltirone II	Danshen
MOL004985	Icos-5-enoic acid	Gancao	MOL007122	Miltirone	Danshen
MOL004980	Inflacoumarin A	Gancao	MOL007121	Miltipolone	Danshen
MOL004978	2-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[6,5-f]chromen-3-yl]-5-methoxyphenol	Gancao	MOL007120	Miltionone II	Danshen
MOL004974	3'-methoxyglabridin	Gancao	MOL007119	Miltionone I	Danshen
MOL004966	3'-hydroxy-4'-O-methylglabridin	Gancao	MOL007118	Microstegiol	Danshen
MOL004961	Quercetin der.	Gancao	MOL007115	Manool	Danshen
MOL004959	1-methoxyphaseollidin	Gancao	MOL007111	Isotanshinone II	Danshen
MOL004957	HMO	Gancao	MOL007108	Isocryptotanshi-none	Danshen
MOL004949	Isolicoflavonol	Gancao	MOL007107	C09092	Danshen
MOL004948	Isoglycyrol	Gancao	MOL007105	Epidanshenspiroketallactone	Danshen
MOL004945	(2S)-7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one	Gancao	MOL007101	Dihydrotanshinone I	Danshen
MOL004941	(2R)-7-hydroxy-2-(4-hydroxyphenyl)chroman-4-one	Gancao	MOL007100	Dihydrotanshinlactone	Danshen
MOL004935	Sigmoidin-B	Gancao	MOL007098	Deoxyneocryptotanshinone	Danshen
MOL004924	(-)-medicocarpin	Gancao	MOL007094	Danshenspiroketallactone	Danshen
MOL004917	Glycyroside	Gancao	MOL007093	Dan-shexinkum d	Danshen
MOL004915	Eurycarpin A	Gancao	MOL007088	Cryptotanshinone	Danshen
MOL004914	1,3-dihydroxy-8,9-dimethoxy-6-benzofurano[3,2-c]chromenone	Gancao	MOL007085	Salvilenone	Danshen
MOL004913	1,3-dihydroxy-9-methoxy-6-benzofurano[3,2-c]chromenone	Gancao	MOL007082	Danshenol A	Danshen
MOL004912	Glabrone	Gancao	MOL007081	Danshenol B	Danshen
MOL004911	Glabrene	Gancao	MOL007079	Tanshinaldehyde	Danshen
MOL004910	Glabranin	Gancao	MOL007077	Sclareol	Danshen
MOL004908	Glabridin	Gancao	MOL007071	Przewaquinone f	Danshen
MOL004907	Glyzaglabrin	Gancao	MOL007070	(6S,7R)-6,7-dihydroxy-1,6-dimethyl-8,9-dihydro-7H-naphtho[8,7-g]benzofuran-10,11-dione	Danshen
MOL004905	3,22-dihydroxy-11-oxo-delta(12)-oleanene-27-α-methoxycarbonyl-29-oic acid	Gancao	MOL007069	Przewaquinone C	Danshen
MOL004904	Licopyranocoumarin	Gancao	MOL007068	Przewaquinone B	Danshen
MOL004903	Liquiritin	Gancao	MOL007064	Przewalskin B	Danshen
MOL004898	(E)-3-[3,4-dihydroxy-5-(3-methylbut-2-enyl)phenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one	Gancao	MOL007063	przewalskin a	Danshen
MOL004891	Shinpterocarpin	Gancao	MOL007061	Methylenetanshinquinone	Danshen
MOL004885	Licoisoflavanone	Gancao	MOL007058	Formyltanshinone	Danshen
MOL004884	Licoisoflavone B	Gancao	MOL007051	6-O-syringyl-8-o-acetyl shanzhiside methyl ester	Danshen
MOL004883	Licoisoflavone	Gancao	MOL007050	2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-3-benzofurancarboxaldehyde	Danshen
MOL004882	Licocoumarone	Gancao	MOL007049	4-methylenemiltirone	Danshen
MOL004879	Glycyrin	Gancao	MOL007048	(E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-benzofuran-4-yl]acrylic acid	Danshen
MOL004866	2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-(3-methylbut-2-enyl)chromone	Gancao	MOL007045	3α-hydroxytanshinone IIa	Danshen
MOL004864	5,7-dihydroxy-3-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromone	Gancao	MOL007041	2-isopropyl-8-methylphenanthrene-3,4-dione	Danshen
MOL004863	3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-enyl)chromone	Gancao	MOL007036	5,6-dihydroxy-7-isopropyl-1,1-dimethyl-2,3-dihydrophenanthren-4-one	Danshen
MOL004860	Licorice glycoside E	Gancao	MOL006824	α-amyrin	Danshen
MOL004857	Gancaonin B	Gancao	MOL002651	Dehydrotanshinone IIA	Danshen
MOL004856	Gancaonin A	Gancao	MOL002222	Sugiol	Danshen
MOL004855	Licoricone	Gancao	MOL001942	Isoimperatorin	Danshen
MOL004849	3-(2,4-dihydroxyphenyl)-8-(1,1-dimethylprop-2-enyl)-7-hydroxy-5-methoxy-coumarin	Gancao	MOL001771	Poriferast-5-en-3β-ol	Danshen
MOL004848	Licochalcone G	Gancao	MOL001659	Poriferasterol	Danshen
MOL004841	Licochalcone B	Gancao	MOL001601	1,2,5,6-tetrahydrotanshinone	Danshen
MOL004838	8-(6-hydroxy-2-benzofuranyl)-2,2-dimethyl-5-chromenol	Gancao	MOL000569	Digallate	Danshen
MOL004835	Glypallichalcone	Gancao	MOL006967	β-D-Ribofuranoside, xanthine-9	Banxia
MOL004833	Phaseolinisoflavan	Gancao	MOL006957	(3S,6S)-3-(benzyl)-6-(4-hydroxybenzyl)piperazine-2,5-quinone	Banxia
MOL004829	Glepidotin B	Gancao	MOL006937	12,13-epoxy-9-hydroxynonadeca-7,10-dienoic acid	Banxia
MOL004828	Glepidotin A	Gancao	MOL006936	10,13-eicosadienoic	Banxia
MOL004827	Semilicoisoflavone B	Gancao	MOL005030	Gondoic acid	Banxia
MOL004824	(2S)-6-(2,4-dihydroxyphenyl)-2-(2-hydroxypropan-2-yl)-4-methoxy-2,3-dihydrofuro[3,2-g]chromen-7-one	Gancao	MOL003578	Cycloartenol	Banxia
MOL004820	Kanzonols W	Gancao	MOL002714	Baicalein	Banxia
MOL004815	(E)-1-(2,4-dihydroxyphenyl)-3-(2,2-dimethylchromen-6-yl)prop-2-en-1-one	Gancao	MOL002670	Cavidine	Banxia
MOL004814	Isotrifoliol	Gancao	MOL001755	24-ethylcholest-4-en-3-one	Banxia
MOL004811	Glyasperin C	Gancao	MOL000519	Coniferin	Banxia
MOL004810	Glyasperin F	Gancao	MOL000358	β-sitosterol	Banxia
MOL004808	Glyasperin B	Gancao	MOL000072	8β-ethoxy atractylenolide Ⅲ	Baizhu
MOL004806	Euchrenone	Gancao	MOL000049	3β-acetoxyatractylone	Baizhu
MOL004805	(2S)-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-8,8-dimethyl-2,3-dihydropyrano[2,3-f]chromen-4-one	Gancao	MOL000028	α-amyrin	Baizhu
MOL004328	Naringenin	Gancao	MOL000022	14-acetyl-12-senecioyl-2E,8Z,10E-atractylentriol	Baizhu
MOL003656	Lupiwighteone	Gancao	MOL000021	14-acetyl-12-senecioyl-2E,8E,10E-atractylentriol	Baizhu
MOL002565	Medicarpin	Gancao	MOL000020	12-senecioyl-2E,8E,10E-atractylentriol	Baizhu
MOL002311	Glycyrol	Gancao