Establishing delivery route-dependent safety and efficacy of living biodrug mesenchymal stem cells in heart failure patients

Table 3 Jadad scale quality assessment of the included trials (R, randomization; B, blinding; D, dropout)

Ref.	Trial registry	Jadad scale				Quality
		R (0-2)	B (0-2)	D (0-1)	Total
Ascheim et al[21], 2014	NCT01442129	1	1	1	3	High
Perin et al[27], 2015	NCT00721045	2	0	1	3	High
Mathiasen et al[25], 2015	NCT00644410	2	2	1	5	High
Zhao et al[19], 2015	NA	1	0	0	1	Low
Patel et al[23], 2016	NCT01670981	2	2	1	5	High
Butler et al[22], 2017	NCT02467387	1	0	1	2	Low
Xiao et al[29], 2017	NA	1	0	0	1	Low
Florea et al[18], 2017	NCT02013674	2	1	1	4	High
Yau et al[20], 2019	NCT02362646	2	0	1	3	High
Bolli et al[26], 2021	NCT02501811	1	2	1	4	High
Qayyum et al[28], 2023	NCT03092284	1	1	1	3	High
Qayyum et al[28], 2023	NCT02673164	2	2	1	5	High