Initial decrease in the lipoprotein(a) level is a novel prognostic biomarker in patients with acute coronary syndrome

Table 3 Univariate and multivariate analyses to predict major adverse cardiac events

Variable	Univariate cox regression			Multivariate cox regression (model-1)			Multivariate cox regression (model-2)
	HR	95%CI	P value	HR	95%CI	P value	HR	95%CI	P value
Lp(a)Δ0-12	0.96	0.93 to 0.99	0.024a	0.95	0.91 to 0.99	0.022a	0.96	0.92 to 0.99	0.019a
Lp(a) 0 h (baseline)	1.00	0.99 to 1.01	0.960	1.00	0.99 to 1.01	0.503	1.00	0.98 to 1.01	0.956
Age	0.99	0.98 to 1.01	0.481	1.00	0.98 to 1.01	0.833	1.00	0.98 to 1.01	0.721
Sex	1.50	0.97 to 2.33	0.068	1.46	0.89 to 2.37	0.131	1.50	0.94 to 2.40	0.091
Smoking	1.19	0.85 to 1.65	0.305	1.05	0.71 to 1.55	0.803
Diabetes mellitus	1.28	0.91 to 1.79	0.155	1.09	0.72 to 1.65	0.676
Systolic blood pressure	1.00	0.99 to 1.00	0.576	1.00	0.99 to 1.00	0.774
Pulse rate	1.07	0.97 to 1.19	0.192	1.06	0.93 to 1.21	0.388
Hemoglobin A1c	0.99	0.97 to 1.01	0.184	0.99	0.98 to 1.01	0.359
HDL cholesterol	1.00	0.99 to 1.00	0.561	1.00	0.99 to 1.00	0.795
LDL cholesterol	1.01	1.00 to 1.01	0.054
Peak CK-MB	1.00	0.99 to 1.00	0.056				1.00	1.00 to 1.00	0.447
Creatinine	1.16	1.09 to 1.24	< 0.001b				1.13	1.05 to 1.22	< 0.01b
Killip classification	1.50	1.06 to 2.13	0.021a				1.39	0.96 to 2.02	0.078

^aP < 0.05.

^bP < 0.01.

Lp(a): Lipoprotein(a); CK-MB: Creatine kinase-myocardial isoform; MACE: Major adverse cardiovascular events; 95%CI: 95% confidence interval; HR: Hazard ratio.