Left bundle branch pacing set to outshine biventricular pacing for cardiac resynchronization therapy?

Table 1 Ongoing randomized controlled trials comparing the clinical outcomes following left bundle branch-area pacing- or biventricular pacing-cardiac resynchronization therapy

Trial name	Design	Interventions arm	Unique identifier	n	Primary endpoint
LeCaRt trial	RCT	LBBP-CRT vs BiVP-CRT	NCT05365568	170	Composite of death, HF hospitalization or worsening HF
LEFT-BUNDLE-CRT trial	RCT	LBBP-CRT vs BiVP-CRT	NCT05434962	176	Positive CRT response: improved clinical composite score or > 15% reduction in LVESV
RAFT-P & A trial	RCT	AV nodal ablation + LBBP-CRT vs AV nodal ablation + BiVP-CRT	NCT05428787	284	Change in NT-ProBNP at 6 months follow-up
Left vs left trial	RCT	HBP/LBBP-CRT vs BiVP-CRT	NCT05650658	2136	All-cause mortality and HF hospitalization at 5.5 yr

AV: Atrioventricular; BiVP: Biventricular pacing; CRT: Cardiac resynchronization therapy; HBP: His-bundle pacing; HF: Heart failure; LBBP: Left bundle branch-area pacing; LVESV: Left ventricular end-systolic volume; ProBNP: Pro-brain natriuretic peptide; RCT: Randomized controlled trial.