Independent prognostic value of lipocalin-2 in congenital heart disease-associated pulmonary artery hypertension

Table 4 Univariate logistic regression analysis to determine the related factors of pulmonary arterial hypertension and lipocalin-2

Variables	Correlation with PAH			Correlation with LCN21
	OR	95%CI	P value	OR	95%CI	P value
Sex, males	1.1	0.366-3.303	0.865	1.212	0.463 ± 3.172	0.696
Age in months	1.05	0.985-1.119	0.137	1.050	1.002 ± 1.101	0.043
BMI	0.868	0.669-1.127	0.289	0.859	0.676 ± 1.091	0.213
Creatinine in μmol/L	1.204	1.066-1.359	0.003	1.021	0.952 ± 1.094	0.566
BUN in mmol/L	1.684	1.089-2.606	0.019	0.967	0.711 ± 1.316	0.832
Albumin in g/L	1.114	0.942-1.317	0.205	1.050	0.930 ± 1.186	0.432
Glucose in mmol/L	0.648	0.346-1.213	0.175	0.763	0.431 ± 1.350	0.353
Hemoglobin in g/L	1.017	0.982-1.053	0.345	1.006	0.977 ± 1.036	0.686
Platelets as 109/L	1	0.995-1.006	0.887	0.999	0.995 ± 1.004	0.841
White blood cells as 109/L	1.259	0.960-1.651	0.096	1.111	0.908 ± 1.361	0.306
SBP in mmHg	1.036	0.984-1.091	0.176	1.018	0.977 ± 1.060	0.401
DBP in mmHg	0.998	0.955-1.044	0.944	1.027	0.983 ± 1.073	0.239
EF as %	1.099	0.966-1.250	0.152	0.932	0.834 ± 1.040	0.207
Diameter in mm	1.106	0.944-1.296	0.211	1.011	0.883 ± 1.157	0.877
mPAP in mmHg	-	-	-	1.084	1.026 ± 1.145	0.004
LCN2 in ng/mL	1.107	1.033-1.185	0.004	-	-	-
ET-1 in μg/mL	10.028	0.896-112.196	0.061	2.101	0.887 ± 4.979	0.092

¹Variable was binarized based on its median value.

BMI: Body mass index; BUN: Blood urea nitrogen; DBP: Diastolic blood pressure; EF: Ejection fraction; ET-1: Endothelin-1; LCN2: Lipocalin-2; mPAP: Mean pulmonary artery pressure; OR: Odds ratio; PAH: Pulmonary arterial hypertension; SBP: Systolic blood pressure.