Independent prognostic value of lipocalin-2 in congenital heart disease-associated pulmonary artery hypertension

Table 1 Baseline characteristics of the nonpulmonary arterial hypertension and pulmonary arterial hypertension patients

Variables	Total number	nonPAH	PAH	P value
Number	69	18	51	-
Sex, number of males	69	7 (38.9)	21 (41.2)	0.866
Age in months	69	8.5 (5.4, 12.0)	11.0 (7.0,19.0)	0.094
BMI	68	15.4 (13.8, 17.4)	15.1 (14.1, 16.6)	0.451
Creatinine in μmol/L	68	21.8 (18.0, 26.5)	27.8 (24.3, 33.6)	< 0.001
BUN in mmol/L	68	3.0 (2.1, 3.7)	4.2 (2.8, 5.1)	0.015
Albumin in g/L	67	42.6 (39.6, 43.7)	43.5 (41.4, 45.3)	0.243
Glucose in mmol/L	65	4.6 (4.1, 5.0)	4.1 (3.8, 4.4)	0.036
Hemoglobin in g/L	69	116 (101, 123)	118 (108, 128)	0.448
Platelets as 109/L	69	276 (247, 314)	267 (221, 344)	0.995
White blood cells as 109/L	46	8.3 (5.7, 9.7)	8.7 (7.5, 11.0)	0.140
SBP in mmHg	66	93.0 (84.5, 95.0)	95.0 (86.5, 101.5)	0.144
DBP in mmHg	66	55.0 (48.5, 60.0)	55.0 (45.0, 60.0)	0.860
EF as %	67	65.0 (62.0, 66.3)	65.0 (65.0, 69.5)	0.072
Diameter in mm	66	10.0 (7.5, 13.0)	10.0 (8.0, 14.8)	0.219
mPAP in mmHg	69	17.7 (16.7, 18.8)	29.4 (24.6, 40.1)	< 0.001
LCN2 in ng/mL	69	19.3 (16.9, 27.6)	33.4 (23.9, 46.3)	< 0.001
ET1 in μg/mL	69	0.14 (0.07, 0.31)	0.30 (0.10, 0.72)	0.049

Data are n (%). Sex is expressed as a proportion; continuous variables are expressed as median (Q1, Q3). Diameter means the diameter of the defect, which was measured during surgery. BMI: Body mass index; BUN: Blood urea nitrogen; DBP: Diastolic blood pressure; EF: Ejection fraction; ET-1: Endothelin-1; LCN2: Lipocalin-2; mPAP: Mean pulmonary artery pressure; PAH: Pulmonary arterial hypertension; SBP: Systolic blood pressure.