Do changes in intracoronary pressure aid coronary spasm diagnosis using the spasm provocation test?

Table 2 Characteristics of lesions based on the occurrence of coronary spasms during spasm provocation tests and the dose of acetylcholine

	Group N	Group L	Group MH	P value
n	49	25	58
RCA/LAD	27/22	9/16	27/31	0.290
Atherosclerosis (%)	23 (47)	9 (36)	28 (48)	0.568
Unavoidable use of NTG	4 (8)	3 (12)	5 (9)	0.851
Coronary spasm
Focal/diffuse		8/17	14/44
Proximal/mid/distal		4/15/6	5/35/18
iFR	0.98 ± 0.04	0.92 ± 0.09	0.98 ± 0.06	0.104
n	15	5	11
Pd/Pa
Baseline	0.98 ± 0.04	0.94 ± 0.05	0.96 ± 0.05	0.001
Low dose of ACh	0.96 ± 0.05	0.72 ± 0.14	0.90 ± 0.06	< 0.001
Pd/Pa (Low dose-baseline)	−0.03 ± 0.03	−0.22 ± 0.14	−0.06 ± 0.05	< 0.001
Moderate-high doses of ACh	0.93 ± 0.06		0.78 ± 0.13	< 0.001
FFR	1.01	0.81 ± 0.09	0.87 ± 0.09	0.093
n	1	6	13

Coronary arteries with coronary spasms at low doses of Acetylcholine (Ach) were defined as group L, and those with coronary spasms at moderate or high doses were defined as group MH. Those who did not occur coronary spasms at any ACh dose were designated as group N. ACh: Acetylcholine; FFR: Fractional flow reserve; iFR: Instantaneous free-wave ratio; LAD: Left anterior descending coronary artery; NTG: Nitroglycerin; Pa: Aortic pressure; Pd: Distal pressure; RCA: Right coronary artery.