Pharmacoepidemiologic study of association between apparent treatment resistant hypertension, cardiovascular disease and interaction effect by sex and age

Table 4 Joint impact of age, sex, and apparent treatment resistant hypertension on cardiovascular disease and coronary heart disease risk

	Sex	Age	HR	(95%CI)
Risk for CVD
aTRH
No	Female	< 65	Reference
No	Male	< 65	1.55	(1.43-1.67)
No	Female	65+	1.68	(1.56-1.79)
No	Male	65+	1.95	1.70-2.20)
Yes	Male	65+	1.85	(1.22-2.48)
Yes	Female	< 65	1.88	(1.64-2.11)
Yes	Male	< 65	2.17	(1.76-2.58)
Yes	Female	65+	2.61	(2.20-3.01)
Three-way interaction of sex, age, and aTRH on CVD, P = 0.2841
Risk for CHD
aTRH
No	Female	< 65	Reference
No	Male	< 65	1.72	(1.57-1.86)
No	Female	65+	1.59	(1.44-1.74)
No	Male	65+	2.1	(1.77-2.42)
Yes	Male	65+	2.12	(1.28-2.97)
Yes	Female	< 65	1.79	(1.47-2.11)
Yes	Male	< 65	2.37	(1.82-2.92)
Yes	Female	65+	2.53	(1.98-3.08)
Three-way interaction of sex, age, and aTRH on CHD, P = 0.4246

CVD: Cardiovascular disease; HR: Hazards ratio; aTRH: Apparent treatment resistant hypertension; CHD: Coronary heart disease.