Pharmacoepidemiologic study of association between apparent treatment resistant hypertension, cardiovascular disease and interaction effect by sex and age

Table 2 Hazard ratios of apparent treatment resistant hypertension for cardiovascular disease risk and sensitivity analyses

	Model 1			Model 2			Model 3
	HR	95%CI		HR	95%CI		HR	95%CI
aTRH	1.51	1.39	1.64	1.49	1.37	1.62	1.3	1.19	1.42
Sensitivity analyses
Propensity score							1.33	1.20	1.48
Multiple imputation sensitivity analysis							1.24	1.16	1.33
CHD							1.56	1.29	1.89
Without uncontrolled on < 3 drugs							1.3	1.18	1.44

aTRH: Apparent treatment resistant hypertension; HR: Hazards ratio; Model 1: Crude; Model 2: Adjusted for age and sex; Model 3: Adjusted for age, sex, region, race, body mass index, diabetes; GFR: Growth factor receptor, history of CHD, history of myocardial infarction (MI)/Stroke, history of coronary revascularization, baseline systolic blood pressure (BP), baseline diastolic BP, left ventricular hypertrophy, smoking status, baseline BP medication use, aspirin, lipid lowering trial. Propensity score weighting sensitivity analysis (model 3). Multiple imputation sensitivity analysis (model 3); CHD: Coronary heart disease-outcome CHD (fatal CHD or nonfatal MI, coronary revascularization, or hospitalized angina) (model 3).