Atrial fibrillation and coronary artery disease: An integrative review focusing on therapeutic implications of this relationship

doi:10.4330/wjc.v15.i5.229

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May 26, 2023 (publication date) through Feb 2, 2025

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. May 26, 2023; 15(5): 229-243
Published online May 26, 2023. doi: 10.4330/wjc.v15.i5.229

Table 2 Impact of various antidiabetic agents on the burden of atrial fibrillation and coronary artery disease and their surrogate endpoints

Antidiabetic drug class	Impact on AF burden/ surrogate end points	Impact on CAD burden/ surrogate end points
Insulin[71]	Increased (↑)	Neutral or increased (-/↑)
Metformin[72]	Reduced (↓)	Reduced (↓)
Sulfonylureas[71]	Neutral (-/↑)	Increased (↑↑)
Thiazolidinediones[73]	Reduced or neutral (-/↓)	Increased (↑↑)
DPP-4 inhibitors[74]	Reduced (-/↓)	Reduced (↓)
GLP-1 receptor agonists[75]	Neutral or slightly increased (-/↑)	Reduced (↓↓)
SGLT-2 inhibitors[76]	Reduced (↓↓)	Reduced (↓↓↓)

AF: Atrial fibrillation; CAD: Coronary artery disease; DPP-4: Dipeptidyl peptidase-4; GLP-1: Glucagon-like peptide 1; SGLT-2: Sodium-glucose cotransporter-2.

Citation: Batta A, Hatwal J, Batta A, Verma S, Sharma YP. Atrial fibrillation and coronary artery disease: An integrative review focusing on therapeutic implications of this relationship. World J Cardiol 2023; 15(5): 229-243
URL: https://www.wjgnet.com/1949-8462/full/v15/i5/229.htm
DOI: https://dx.doi.org/10.4330/wjc.v15.i5.229