Copyright
©The Author(s) 2023.
World J Cardiol. May 26, 2023; 15(5): 205-216
Published online May 26, 2023. doi: 10.4330/wjc.v15.i5.205
Published online May 26, 2023. doi: 10.4330/wjc.v15.i5.205
RCTs | Target population | UF device | Primary and secondary endpoint | Results |
RAPID-CHF (2005) | ADHF, n = 40 | Aquadex system, 8-h course | Weight loss at 24 h of treatment (Primary endpoint); Volume removal after 24 h | Weight reduction resulted not statistically significant (P = 0.24); Volume removal was significantly more in UF arm (P < 0.001) |
UNLOAD (2007) | ADHF, n = 200 | Aquadex System, Mean fluid removal rate 241 mL/h | Weight loss at 48 h; Dyspnea score at 48 h | Weight loss resulted significantly increased in UF arm (P < 0.001), whereas there were no differences between groups in Dyspnea score (P = 0.588) |
ULTRADISCO (2011) | ADHF, n = 30 | PRISMA, treatment duration 46 h | Changes in hemodynamics assessed using PRAM: SVi, CI, CPO, SVR were measured during hospitalization, at discharge, and at 1 and 3-mo follow-up | UF arm as compare to standard care had a significant improvement of global hemodynamic status |
CARRESS-HF (2012) | ADHF, n = 188; Recent increase in serum creatinin >/= 0.3 mg/dL | Aquadex System at a fixed rate of 200 mL/h | Bivariate changes in sCr and change in weight 96 h after randomization | |
CUORE (2014) | ADHF, LVEF </=40%, n = 56 | Dedyca system | HF rehospitalization at 1 yr | UF arm has a significant lower endpoint incidence (P = 0.002) |
AVOID-HF (2016) | ADHF, n = 224 | Aquadex system at an ajdusted rate on a per protocol established basis | Time to first HF event (HF rehospitalization or unscheduled outpatient or emergency treatment with intravenous loop diuretic agents or UF) within 90 days of hospital discharge | 30-d HF rehospitalizations: 11 of 2876 (UF arm) vs 24 of 2882 (diuretics arm), P = 0.06 |
Hu et al[49], 2021 | ADHF, n = 100 | FQ-16 type HF ultrafiltration dehydration device (Beijing Hartcare Medical Technology Co., Ltd) | Weight loss and an increase in urine output on days 4 and 8 of treatment; Secondary outcome evaluated: BNP, NYHA class, IVC collapse index, JVP | Early ultrafiltration group had a significantly greater weight loss (P < 0.001) than the torasemide + tolvaptan group and urine increase (P < 0.001); Secondary outcomes that were followed up demonstated a clear trend towards benefits of UF as compared to diuretics arm |
- Citation: Urbani A, Pensotti F, Provera A, Galassi A, Guazzi M, Castini D. Extracorporeal veno-venous ultrafiltration in congestive heart failure: What’s the state of the art? A mini-review. World J Cardiol 2023; 15(5): 205-216
- URL: https://www.wjgnet.com/1949-8462/full/v15/i5/205.htm
- DOI: https://dx.doi.org/10.4330/wjc.v15.i5.205