Perioperative coagulation activation after permanent pacemaker placement

doi:10.4330/wjc.v15.i4.174

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Apr 26, 2023 (publication date) through Apr 18, 2025

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Apr 26, 2023; 15(4): 174-183
Published online Apr 26, 2023. doi: 10.4330/wjc.v15.i4.174

Table 3 Perioperative coagulation parameters in patients on antiplatelet (n = 55) and anticoagulant (n = 91) therapy

Variable	Antithrombotic therapy	Before implantation	7 d after implantation	30 d after implantation	P value
FI	Antiplatelet	2.66 (2.13-2.99)	2.85 (2.47-3.3)	2.56 (2.19-3.16)	0.513
	Anticoagulant	2.55 (1.9-3.19)	2.58 (1.93-3.44)	2.49 (2.16-2.85)	0.957
	P value	0.675	0.092	0.599	-
FII	Antiplatelet	156.9 (94.5-237.3)	139 (86.8-192.5)	163.5 (112.4-203)	0.289
	Anticoagulant	186.2 (113.8-256.8)	118.5 (86.8 -173)	128.4 (99.6-170.5)	0.067
	P value	0.458	0.609	0.263	-
FV	Antiplatelet	164.9 (103.4-267.5)	115.5 (92.8-198.9)	98.6 (82.6-155.3)	0.245
	Anticoagulant	133.3 (96.6-187.9)^a^,^b	80.1 (45.9-152.8)	73.4 (55.4-84.3)	0.005
	P value	0.196	0.033	0.004	-
FVII	Antiplatelet	203.4 (113-352.1)	200 (116.4-438.3)	223 (107.9-376.6)	0.683
	Anticoagulant	182.1 (87.3-384.6)	122.3 (80.3-209.9)	83.7 (64.6-154.8)	0.153
	P value	0.691	0.024	0.002	-
FVIII	Antiplatelet	82.1 (62.5-114.3)	81.6 (63.8-97.5)	75.5 (59.1-100.5)	0.104
	Anticoagulant	78.5 (58.7-99.7)^a^,^b	59.6 (41.7-82)	55.1 (40.8-84.4)	0.001
	P value	0.21	0.001	0.033	-
FIX	Antiplatelet	85.4 (74.8-106.9)	84.2 (78-105.8)	96.7 (87.2-104)	0.438
	Anticoagulant	87 (68.4-99.6)^a^,^b	69.6 (55.6-81.8)	63.2 (45.5-76.8)	0.004
	P value	0.331	<0.001	<0.001	-
FX	Antiplatelet	200 (105.8-308.2)	163.8 (81.7-228.4)	171.6 (120.2-240)	0.708
	Anticoagulant	187.8 (98.6-286.1)^a^,^b	152.6 (89-248.2)	109.8 (82-163.5)	0.007
	P value	0.837	0.983	0.03	-
FXI	Antiplatelet	87.2 (69.8-100.8)	93.8 (63.1-108.2)	96.7 (84.2-108)	0.957
	Anticoagulant	74.8 (62.5-106.9)^a^,^b	61 (49.9-82.6)	59.5 (47.5-86.5)	< 0.001
	P value	0.377	0.001	< 0.001	-
FXII	Antiplatelet	82 (65.8-101.9)^a	79.9 (63.3-97.1)	89.7 (75.7-102.5)	0.01
	Anticoagulant	80.7 (69.4-110.2)^a^,^b	78.9 (63.4-97)	73.8 (69.8-90.3)	0.001
	P value	0.989	0.629	0.027	-

^aP < 0.05 vs 7 d after pacemaker implantation.

^bP < 0.05 vs 30 d after pacemaker implantation.

FI: Factor I; FII: Factor II; FV: Factor V; FVII: Factor VII; FVIII: Factor VIII; FIX: Factor IX; FX: Factor X; FXI: Factor XI; FXII: Factor XII.

Citation: Kalinin R, Suchkov I, Povarov V, Mzhavanadze N, Zhurina O. Perioperative coagulation activation after permanent pacemaker placement. World J Cardiol 2023; 15(4): 174-183
URL: https://www.wjgnet.com/1949-8462/full/v15/i4/174.htm
DOI: https://dx.doi.org/10.4330/wjc.v15.i4.174