Right ventricle dysfunction does not predict mortality in patients with SARS-CoV-2-related acute respiratory distress syndrome on extracorporeal membrane oxygenation support

Table 1 Comparison between patients with right ventricle dilatation and dysfunction and those without, n %

Variable	All patients	RVDD (No. 34)	No RVDD (No. 27)	P value
Clinical data
Age (yr), mean ± SD	54.3 ± 10.3	53.8 ± 9.7	52.9 ± 11	0.735
Gender, M/F	45/16 (74/26)	28/6 (82/18)	17/10 (63/37)	0.087
BMI (kg/m2), mean ± SD	32.9 ± 5.3	32.4 ± 5.6	32.7 ± 4.9	0.836
Charlson index, median (IQR)	2.0 (1.0-3.0)	2.0 (1.0-3.0)	2.0 (1.0-3.0)	0.772
Transferred from peripheral hospitals	38 (62)	18 (52)	20 (74)	0.9
Time from symptoms’ onset to ICU (d), median (IQR)	13 (10-13)	9 (8-12)	12 (10-14)	0.075
SOFA, median (IQR)	8.0 (7.0-10.0)	10 (8-10)	7 (6-10)	0.029
Mechanical ventilation length to ECMO support (d), median (IQR)	6.0 (8.0-11.0)	8.5 (6-12)	7 (4-10)	0.046
ECMO duration (d), median (IQR)	22 (13-42)	24.5 (9-44)	21 (15-35)	0.765
Renal replacement therapy	29 (48)	22 (65)	7 (26)	0.002
ICU death	33 (54.1)	21 (62)	12 (44)	0.024
Biohumoral data
Creatinine (mg/dL), median (IQR)	1.00 (0.72-1.86)	0.83 (0.61-1.34)	1.65 (0.78-2.00)	0.025
D-dimer (ng/mL), median (IQR)	3594 (2252-7214)	3748 (1740-12085)	3550 (2368-5007)	0.425
CRP (mg/dL), median (IQR)	142 (88-144)	121 (87-174)	165 (98-212)	0.55
IL-6 (pg/mL), median (IQR)	34 (7.4-70.0)	45 (6.9-105.0)	34 (21-58.0)	0.772
Troponin (pg/mL), median (IQR)	21 (14.0-38.0)	33.0 (14.0-112.0)	21.0 (8.5-48.0)	0.253
NT-pro BNP (pg/mL), median (IQR)	874 (345-1654)	735 (252-1467)	1273 (585-1868)	0.058
LDH IU/L, median (IQR)	465 (375-538)	421 (363-510)	473 (424-542)	0.078
Echocardiographic data
LVEF (%), mean ± SD	63.9 ± 7.6	64.3 ± 7.9	64.5 ± 7.5	0.113
RV/LV, mean ± SD	0.58 ± 0.17	0.69 ± 0.08	0.45 ± 0.14	0.0001
TAPSE (mm), mean ± SD	18.0 (10.0-21.0)	13.9 (10.0 ± 14.5)	17.4 (16.0-22.5)	0.015
sPAP (mmHg), mean ± SD	58.4 ± 9.4	64 ± 11	59.1 ± 7.7	0.015
e/e1	11 ± 3	12 ± 3	9 ± 3	0.0003
TAPSE/sPAP (mm/mmHg), mean ± SD	0.28 ± 0.13	0.19 ± 0.10	0.28 ± 0.11	0.001
Ventilatory parameters
PEEP (cm H2O), mean ± SD	12.2 ± 2.3	12.4 ± -2.4	12.1 ± 2.6	0.64
PO2/FiO2, mean ± SD	62 (50-88)	66 (54-88)	60 (50-88)	0.442
Norepinephrine, mean ± SD	0.34 ± 0.22	0.39 ± 0.26	0.24 ± 0.10	0.011

IQR: Interquartile range; RVDD: Right ventricle dilatation and dysfunction; BMI: Body mass index; ICU: Intensive care unit; LOS: Length of stay; CRP: C-reactive protein; IL-6: Interleukin 6, SOFA: Simplified organ functional assessment; ECMO: Extracorporeal membrane oxygenation; NT pro BNP: N terminal pro brain natriuretic peptide; RV: Right ventricle; LV: Left ventricle; EF: Ejection fraction; TAPSE: Tricuspid annular plane systolic excursion; sPAP: Systolic pulmonary arterial pressure; LDH: Lactate dehydrogenase; LVEF: Left ventricular ejection fraction; PEEP: Positive end-expiratory pressure.