Effect of reperfusion strategy on QT dispersion in patients with acute myocardial infarction: Impact on in-hospital arrhythmia

Table 5 Studies addressing repolarization changes following reperfusion in ST-segment elevation myocardial infarction

Ref.	Study type	Study population	Time to evaluation	Reduction of QTD and QTcD	In-hospital arrhythmia	Remarks
Lopes et al[21], 2006	Retrospective	Thrombolytic (n = 154)	4 d	Sig. after 4 d	QTD not correlated with arrhythmia	CA after 48 h; Reduction in QTD is a predictor of coronary reperfusion
Ornek et al[22], 2014	Prospective	Thrombolytic (n = 20)	7 d	Sig. after 7 d	QTD correlated with arrhythmia	Use 24-h Holter monitor
Mulay et al[23], 2004	Prospective	STEMI (n = 100) Normal (n = 100)	24 hr On discharge	NA	Sig. high QTD in patients with ventricular arrhythmias compared to those without	Sig. higher QTD on admission, at 24 h, and at discharge than normal subjects
Pan et al[24], 2011	Prospective	PPCI (n = 81)	24 h	Sig. after 24 h	NA	QTcD change was an independent predictor of MACE at 1 yr
Hamza et al[25], 2014	Retrospective	PPCI (n = 54)	90 min 24 hr	Not sig after 90 min Sig. after 24 h	NA
Oni Heris et al[26], 2014	Prospective	Thrombolytic (n = 160)	1 hr 4 d	Not sig. after 1 hr Not sig. after 4 d	NA
Babapour et al[27], 2018	Retrospective	PPCI (n = 77)	24 h	Not sig. after 24 hr	NA
Cavusoglu et al[28], 2001	Prospective	PPCI (n = 21) Thrombolytic (n = 21)	24 h	Sig. in PPCI group Sig. in thrombolytic group Sig. in PPCI compared with thrombolytic	NA
George et al[29], 2015	Prospective	PPCI (n = 25) Thrombolytic (n = 25)	24 h	Sig. in PPCI group Not sig. in thrombolytic group Sig. in PPCI compared with thrombolytic	NA
Valizadeh et al[30], 2020	Prospective	PPCI (n = 70) Thrombolytic (n = 115)	24 h	Sig. in PPCI group Not sig. in thrombolytic group Not sig. in PPCI compared with thrombolytic	QTD mean in patients with arrhythmia was reduced before and after treatment with a significant reduction after PPCI as compared to thrombolysis

CA: Coronary angiogram; MACE: Major adverse cardiovascular event; NA: Not applicable; PPCI: Primary percutaneous coronary intervention; Ref.: Reference; Sig.: Significant; STEMI: ST-elevation myocardial infarction.