Cardiometabolic risk factors in young Indian men and their association with parameters of insulin resistance and beta-cell function

doi:10.4330/wjc.v14.i8.462

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World Journal of Cardiology

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World J Cardiol. Aug 26, 2022; 14(8): 462-472
Published online Aug 26, 2022. doi: 10.4330/wjc.v14.i8.462

Table 4 Comparison of cardiometabolic and glycaemic variables for men depending upon different categories based on beta-cell function (oral disposition index) and insulin resistance

Variable	Phenotype 1 oDI > 75^th and HOMA-IR < 25^th percentile of total cohort n = 67	Phenotype 2 oDI 25^th to 75^th and/or HOMA-IR 25^th to 75^th percentile of total cohort n = 332	Phenotype 3 oDI < 25^th or HOMA-IR > 75^th percentile of total cohort n = 156	*Phenotype 4 oDI < 25^th and HOMA-IR > 75^th percentile of total cohort n =* 80**	P value^a
Age (yr)	33.3 ± 4.5	33.7 ± 5.1	34.0 ± 5.2	35.1 ± 5.3	0.096
Family H/O diabetes	18 (26.9)	113 (34.0)	79 (50.6)	35 (43.8)	0.001
BMI (kg/m²)	23.2 ± 3.3	25.4 ± 3.5	27.1 ± 3.6	28.5 ± 4.0	< 0.001
BMI ≥ 25 kg/m²	20 (29.9)	186 (56.0)	115 (73.7)	67 (83.8)	< 0.001
Waist circumference (cm)	86.9 ± 8.4	92.5 ± 8.9	97.2 ± 8.7	101.0 ± 9.1	< 0.001
Waist circumference ≥ 90 cm	24 (35.8)	222 (66.9)	130 (83.3)	72 (92.3)	< 0.001
Systolic BP ≥ 140 mmHg	3 (4.5)	18 (5.4)	12 (7.7)	13 (16.5)	0.014
Diastolic BP ≥ 90 mmHg	4 (6.0)	45 (13.6)	36 (23.1)	26 (32.9)	< 0.001
Hypertension	6 (9.0)	48 (14.5)	39 (25.0)	30 (38.0)	< 0.001
Total cholesterol ≥ 5.2 mmol/L	10 (14.9)	98 (29.5)	53 (34.2)	32 (40.0)	0.007
LDL-C ≥ 2.6 mmol/L	26 (38.8)	197 (59.3)	96 (61.9)	59 (73.8)	< 0.001
HDL-C < 1.29 mmol/L	33 (49.3)	159 (47.9)	98 (63.2)	46 (57.5)	0.012
Triacylglycerol ≥ 1.7 mmol/L	13 (19.4)	134 (40.4)	86 (55.5)	48 (60.0)	< 0.001
The metabolic syndrome	9 (13.4)	102 (30.7)	91 (58.3)	56 (70.0)	< 0.001
HOMA-IR (mmol/L × µIU/mL)	1.1 (0.7-1.5)	2.4 (1.9-3.0)	4.0 (2.7-5.0)	5.9 (4.7-8.8)	< 0.001
Insulinogenic index (pmol_ins/mmol_glu)	237.4 (156.4-377.1)	228.6 (147.9-348.5)	159.0 (72.8-418.7)	99.9 (57.3-166.1)	< 0.001
Disposition index (l/mmol_glu)	6.5 (5.1-9.4)	3.0 (2.3-4.1)	1.5 (1.0-2.6)	0.7 (0.3-1.1)	< 0.001
Dysglycaemia	19 (28.4)	133 (40.1)	107 (68.6)	72 (90.0)	< 0.001

^aData are the mean ± SD, median (q25-q75), or n (%). H/O: History of; BMI: Body mass index; BP: Blood pressure; LDL-C: Low density lipoprotein-cholesterol; HDL-C: High density lipoprotein-cholesterol; HOMA-IR: Homeostatic model assessment for insulin resistance.

Citation: Gupta Y, Goyal A, Kalaivani M, Tandon N. Cardiometabolic risk factors in young Indian men and their association with parameters of insulin resistance and beta-cell function. World J Cardiol 2022; 14(8): 462-472
URL: https://www.wjgnet.com/1949-8462/full/v14/i8/462.htm
DOI: https://dx.doi.org/10.4330/wjc.v14.i8.462