Meta-Analysis
Copyright ©The Author(s) 2022.
World J Cardiol. Apr 26, 2022; 14(4): 250-259
Published online Apr 26, 2022. doi: 10.4330/wjc.v14.i4.250
Table 1 General characteristics of included studies
Ref.
Design
Procedure
Definition of vasoplegia
Total sample
Vasoplegia (%)
ACEI (%)
Tuman et al[14]Case-controlCoronary artery and/or valve surgery requiring CPBPost-CPB ≥ 2 vasoconstrictors with adequate cardiac output43014.512.1
Bruce et al[16]Case-controlCardiac surgery requiring CPBMAP ≤ 50 mmHg, indexed SVR ≤ 1400 dynes s/cm5/m2, cardiac index ≥ 2.2 L/min/m2, requiring norepinephrine infusion18834.042.0
Carrel et al[17]Case-controlCABG or AVRSVR < 600 dynes s/cm5 with adequate cardiac output8007.543.1
Mekontso-Dessap et al[7]Case-controlCABGMAP < 70 mmHg, indexed SVR ≤ 1400 dynes s/cm5/m2, normal cardiac output, requiring vasoconstrictor10833.331.5
Sun et al[15]Case-controlCABGMAP ≤ 70 mmHg, indexed SVR ≤ 1400 dynes s/cm5/m2, cardiac index ≥ 2.5 L/min/m2, and central venous pressure ≥ 10 mmHg6964.738.5
Levin et al[2]Case-controlCardiac surgeryEpinephrine/norepinephrine (≥ 150 ng/kg/min), dopamine (≥ 10 μg/kg/min) or vasopressin (≥ 4 U/h)282320.419.7
Shahzamani et al[6]Case-controlCABGMAP < 65 mmHg, normal cardiac output, requiring vasoconstrictor30017.064.0
Radaelli et al[19]Case-controlCardiac surgery3 of these 4: MAP < 65 mmHg, indexed SVR ≤ 1600 dynes s/cm5/m2, cardiac index ≥ 2.5/min/m2, and requirement of norepinephrine (> 0.03 μg/kg/min) or vasopressin313932.552.1
Suga et al[5]Case-controlCABGInotropic support post-CABG56211.79.1
Miceli et al[18]Case-controlCABGInotropic support post-CABG265543.551.0
Pigot et al[21]RCTCABGInotropic support post-CABG4015.0100
van Diepen et al[20]RCTCABG or valve surgeryMAP < 60 mmHg requiring vasopressor administration for at least 4 h and a central venous pressure ≥ 8 mmHg12129.876.9