Role of genetic testing in cardiomyopathies: Α primer for cardiologists

Table 3 Definitions of the variant classifications

Variant	Definition
Pathogenic	Variant is disease-causing with > 99% confidence; Cascade genetic testing should be offered to family members
Likely pathogenic	Variant is disease-causing with > 90%-95% confidence; Cascade genetic testing should be offered to family members
VUS	Variant is considered uncertain with an unknown effect on clinical phenotype, as there is insufficient or conflicting evidence for pathogenicity; Cascade genetic testing cannot be offered to family members
Likely benign	Variant is probably not disease-causing; Cascade genetic testing should not be offered to family members
Benign	Variant is not disease-causing; Cascade genetic testing should be offered to family members

VUS: Variant of uncertain significance.