Copyright
©The Author(s) 2020.
World J Cardiol. Apr 26, 2020; 12(4): 123-135
Published online Apr 26, 2020. doi: 10.4330/wjc.v12.i4.123
Published online Apr 26, 2020. doi: 10.4330/wjc.v12.i4.123
Table 1 Properties of voltage-gated sodium channel isoforms
Voltage-gated sodium channel isoform | Tissue | Gene | Amino acid length | Activated | Inactivated | Associated β-subunit |
Nav1.1 | Brain | SCN1A | 2009aa (human and rat) | -33 mV | -72 mV | β1, β2, β3, β4 |
Nav1.2 | Brain | SCN2A | 2005aa (human); 2006aa (rat) | -24 mV | -53 mV | β1, β2, β3, β4 |
Nav1.3 | Brain | SCN3A | 1951aa (human and rat) | -23 to -26 mV | -65 to -69 mV | β1 and β3 |
Nav1.4 | Skeletal muscle | SCN4A | 1836aa (human); 1840aa (rat) | -26 to -30 mV | -56 mV | β1 |
Nav1.5 | Heart | SCN5A | 2016aa (human); 1951aa (rat) | -47 mV | -84 mV | β1, β2, β3, β4 |
Nav1.6 | Brain | SCN8A | 1980aa (human); 1976aa (rat) | -37.7 mV | -98 mV | β1 and β2 |
Nav1.7 | PNS | SCN9A | 1977aa (human); 1984aa (rat) | -31 mV | -61 to -78 mV | β1 and β2 |
Nav1.8 | PNS | SCN10A | 1957aa (human) | -16 to -21 mV | -30 mV | Not established |
Nav1.9 | PNS | SCN11A | 1792aa (human); 1765aa (rat) | -47 to -54 mV | -44 to -54 mV | Not established |
- Citation: Isaac E, Cooper SM, Jones SA, Loubani M. Do age-associated changes of voltage-gated sodium channel isoforms expressed in the mammalian heart predispose the elderly to atrial fibrillation? World J Cardiol 2020; 12(4): 123-135
- URL: https://www.wjgnet.com/1949-8462/full/v12/i4/123.htm
- DOI: https://dx.doi.org/10.4330/wjc.v12.i4.123