Safety and efficacy of soluble guanylate cyclase stimulators in patients with heart failure: A systematic review and meta-analysis

Figure 3 Forest plot for the primary composite endpoint overall side-effects showing an individual and pooled risk ratio for randomized controlled trials comparing soluble guanylate cyclase stimulators to control. A: Pooled composite endpoint; B: Overall side-effects. The pooled risk ratio (RR) with 95% confidence interval (CI) were calculated using random-effects models. Weight refers to the contribution of each study to the overall pooled estimate of treatment effect. Each square and horizontal line denotes the point estimate and 95%CI for each trial’s RR, respectively. The diamonds signify the pooled RR; the diamond’s centre denotes the point estimate and width denotes the 95%CI. CI: Confidence interval; sGC: Soluble guanylate cyclase.