Improved scoring system for the electrocardiographic diagnosis of left ventricular hypertrophy

Table 5 Sensitivity, specificity, and positive and negative predictive values of selected electrocardiographic criteria for left ventricular hypertrophy

		Derivation cohort				Validation cohort
Criteria	Cutoff	Sensitivity (95% CI)	Specificity (95% CI)	PPV	NPV	Sensitivity	Specificity
Derived Criteria	1.5 points	67.9 (62.6-72.9)	81.4 (80.3-82.4)	19.0	97.5	62.5	83.2
""	2 points	42.3 (37.0-47.7)	93.0 (92.3-93.7)	28.2	96.2	37.5	93.4
""	2.5 points	30.0 (25.2-35.3)	96.6 (96.1-97.1)	37.6	95.6	30.0	96.8
Cornell	-	37.8 (32.6-43.1)	92.3 (91.6-93.0)	24.1	95.8	36.2	90.3
Sokolow-Lyon	-	16.5 (12.5-20.5)	95.9 (95.4-96.5)	20.7	94.7	20.0	96.3
Cornell Product		55.0 (49.6-60.3)	88.3 (87.5-89.2)	23.3	96.8	53.8	88.1
Sokolow-Lyon Product		22.5 (18.0-27.0)	95.9 (95.3-96.4)	26.0	95.0	23.8	95.6
Gubner-Ungerleider		27.0 (22.3-31.8)	88.9 (88.0-89.8)	13.6	95.0	27.5	87.7
Sum-of-12-Lead		57.4 (51.9-62.7)	76.1 (74.9-77.3)	13.4	96.5	57.5	77.1
Romhilt-Estes	5 points	35.4 (30.3-40.8)	94.4 (93.7-95.0)	26.2	95.8	35.0	95.0
""	4 points	51.1 (45.5-56.5)	88.2 (87.3-89.0)	21.8	96.5	57.5	90.0
Framingham-adjusted Cornell		42.3 (37.0-47.7)	90.1 (89.3-90.9)	21.7	96.0	51.3	87.6
R-wave amplitude in aVL	1.1 mV	20.1 (16.0-24.8)	92.6 (91.8-93.3)	14.9	94.7	21.3	92.1
Peguero-Lo Presti		24.9 (20.3-29.6)	94.7 (94.1-95.3)	23.3	95.1	26.3	93.5

CI: Confidence interval; PPV: Positive predictive values; NPV: Negative predictive values.