Copyright
©The Author(s) 2019.
World J Cardiol. Mar 26, 2019; 11(3): 103-119
Published online Mar 26, 2019. doi: 10.4330/wjc.v11.i3.103
Published online Mar 26, 2019. doi: 10.4330/wjc.v11.i3.103
Table 6 Risk factors for sudden cardiac death in patients with hypertrophic cardiomyopathy
Risk factor studied | Relative risk of SCD | P value | Absolute SCD risk in cohort | Study size | Year | Country |
Age | ||||||
O’Mahony et al[60] | HR 0.99 (0.98-1.00) (Age 42 ± 15) | 0.007 | 5% at 5 years | 3675 | 2014 | Europe |
Syncope | ||||||
Liu et al[61] | HR 2.31 (1.22-4.38) | 12146 | 2017 | USA, China | ||
O’Mahony et al[60] | HR 2.33 (1.69-3.19) | < 0.001 | 5% at 5 years | 3675 | 2014 | Europe |
Christiaans et al[62] | HR 2.68 (0.97–4.38) | 9357 | 2010 | Netherlands, UK | ||
Family history of SCD | ||||||
Christiaans et al[62] | HR 1.27 (1.16–1.38) | 9357 | 2010 | Netherlands, UK | ||
O’Mahony et al[60] | HR 1.76 (1.32-2.24) | <0.001 | 5% at 5 years | 3675 | 2014 | Europe |
Liu et al[61] | HR 2.34 (1.46- 3.75) | 12146 | 2017 | USA, China | ||
Abnormal blood pressure response during exercise | ||||||
Liu et al[61] | HR 1.38 (0.65-2.89) (BP dropping on excersice) | 12146 | 2017 | USA, China | ||
Christiaans et al[62] | HR 1.30 (0.64–1.96) (BP dropping on excersice) | 9357 | 2010 | Netherlands, UK | ||
Non sustained ventricular tachycardia | ||||||
Liu et al[61] | HR 2.92 (1.97-4.33) | 12146 | 2017 | USA, China | ||
Sugrue et al[63] | HR 3.36 (1.00-11.35) | 0.05 | 52 | 2017 | USA | |
O’Mahony et al[60] | HR 2.53 (1.85-3.47) | < 0.001 | 5% at 5 years | 3675 | 2014 | Europe |
Christiaans et al[62] | HR 2.89 (2.21–3.58) | 9357 | 2010 | Netherlands, UK | ||
Left ventricular wall thickness/hypertrophy | ||||||
Liu et al[61] | HR 3.17 (1.64-6.12) (Maximum LV wall thickness ≥ 30 mm) | 12146 | 2017 | USA, China | ||
Maeda et al[64] | HR 1.21 (1.04–1.39) (Maximum left ventricular wall thickness per 1-mm increase) | 0.011 | 593 | 2016 | Japan | |
O’Mahony et al[60] | HR 1.05 (1.03-1.07) (Maximal LV wall thickness in mm 21.5 ± 6) | < 0.001 | 5% at 5 years | 3675 | 2014 | Europe |
Christiaans et al[62] | HR 3.10 (1.81–4.40) (LVH ≥ 20 mm) | 9357 | 2010 | Netherlands, UK | ||
Left ventricular outflow tract obstruction | ||||||
Liu et al[61] | HR 2.41 (1.55-3.73) | 12146 | 2017 | USA, China | ||
O’Mahony et al[60] | HR 1.01 (1.00-1.01) [LVOT Gradient mmHG 18 (6-58)] | 0.005 | 5% at 5 years | 3675 | 2014 | Europe |
Left atrial diameter | ||||||
O’Mahony et al[60] | HR 1.04 (1.02-1.05) (LA diameter in mm 46.2 ± 9) | < 0.001 | 5% at 5 years | 3675 | 2014 | Europe |
- Citation: Khan HM, Leslie SJ. Risk factors for sudden cardiac death to determine high risk patients in specific patient populations that may benefit from a wearable defibrillator. World J Cardiol 2019; 11(3): 103-119
- URL: https://www.wjgnet.com/1949-8462/full/v11/i3/103.htm
- DOI: https://dx.doi.org/10.4330/wjc.v11.i3.103