Novel lipid-modifying therapies addressing unmet needs in cardiovascular disease

doi:10.4330/wjc.v11.i11.256

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Nov 26, 2019 (publication date) through Jun 25, 2024

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Nov 26, 2019; 11(11): 256-265
Published online Nov 26, 2019. doi: 10.4330/wjc.v11.i11.256

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Figure 1 Molecular pathways of action and effects of novel lipid-modifying therapies addressing unmet needs in cardiovascular disease. siRNA: Small interfering RNA; ACL: Adenosine triphosphate-citrate lyase; AMPK: Adenosine monophosphate-activated protein kinase; PPARs: Peroxisome proliferator-activated receptors; Apo: Apolipoprotein; ASO: Antisense oligonucleotide; PCSK9: Proprotein convertase subtilisin/kexin type 9; HMG-CoA: 3-hydroxy-3-methylglutaryl-CoA; Lp(a): Lipoprotein (a); LXRs: Liver X receptors; LDL-C: Low-density lipoprotein cholesterol; CEC: Cholesterol efflux capacity.

Citation: Kosmas CE, Sourlas A, Silverio D, Montan PD, Guzman E. Novel lipid-modifying therapies addressing unmet needs in cardiovascular disease. World J Cardiol 2019; 11(11): 256-265
URL: https://www.wjgnet.com/1949-8462/full/v11/i11/256.htm
DOI: https://dx.doi.org/10.4330/wjc.v11.i11.256