NBCe1 Na+-HCO3- cotransporter ablation causes reduced apoptosis following cardiac ischemia-reperfusion injury in vivo

Figure 3 Cardiovascular performance in WT and KO mice. Intraventricular and intra-arterial pressure measurements were recorded using transducers in the left ventricle and right femoral artery of anesthetized 2-3 mo old WT (Slc4a4^flx/flx) and KO (Slc4a4^flx/flx(Cre)) mice under both basal conditions and in response to β-adrenergic stimulation (intravenous infusion of increasing doses of dobutamine). A: Heart rate; B: Systolic left ventricular pressure; C: Mean arterial pressure; D: Positive dP/dt in mm Hg/sec; E: Positive dP/dt at 40 mm Hg; F: Negative dP/dt in mm Hg/sec is shown for WT and KO mice. n = 8 WT (4 female, 4 male) and 8 KO (4 female, 4 male) mice.