Incidence and risk factors for potentially suboptimal serum concentrations of vancomycin during cardiac surgery

Table 3 Risk factors for vancomycin levels under 10 mg/L - univariate binary logistic model

	OR	95%CI	P-value
CPB (off-pump vs on-pump)	0.51	0.20-1.30	0.156
Vancomycin infusion (stopped vs non-stopped)	0.6	0.17-2.10	0.421
Age at surgery (> 70 yr vs ≤ 70 yr)	0.54	0.32-0.92	0.021
Gender (Female vs male)	0.44	0.26-0.76	0.003
BMI (> 25 vs ≤ 25)	2.3	1.36-3.88	0.002
Fluid balance (> 2000 mL vs ≤ 2000 mL)	1.44	0.86-2.41	0.163
CrCl (> 70 mL/min vs ≤ 70 mL/min)	2.56	1.51-4.34	<0.001
Vancomycin dosage (> 15 mg/kg vs ≤ 15 mg/kg)	0.38	0.21-0.66	0.001
Vancomycin infusion duration			0.237
50-59 min vs < 50 min	0.5	0.21-1.21	0.123
60 min vs < 50 min	0.63	0.28-1.42	0.26
61-70 min vs < 50 min	0.48	0.14-1.69	0.254
> 70 min vs < 50 min	1.2	0.44-3.31	0.719

BMI: Body mass index; CPB: Cardiopulmonary bypass; CrCl: Creatinine clearance.