Incidence and risk factors for potentially suboptimal serum concentrations of vancomycin during cardiac surgery

Table 2 Pharmacokinetic comparison between patients with at least 1 serum sample with a vancomycin concentration <10 mg/L (in the left column) and patients without serum samples with a vancomycin concentration <10 mg/L (in the right column)

	Vancomycin levels < 10 mg/L (n = 114)	Vancomycin levels ≥ 10 mg/L (n = 122)	P-value
Cmax (mg/L)	33.2 (6.2-122.0)	57.9 (14.6-210.0)	<0.001
AUC (mg*h/L)	119.2 (28.3-247.7)	191.7 (95.8-467.8)	<0.001
t1/2 (h)	3.9 (1.6-9.2)	4.0 (1.3-9.8)	0.437
CL (L/h)	8.4 (4.0-35.3)	5.2 (2.1-10.4)	<0.001
Vd (L)	47.2 (16.5-195.2)	29.8 (12.4-63.3)	<0.001

AUC: Area under the curve; CL: Total body clearance; C_max: Maximum concentration; t_½: Elimination half-life; V_d: Volume of distribution.