Undiscovered pathology of transient scaffolding t1remains a driver of failures in clinical trials

Figure 7 Arterial remodeling in coronary arteries after transient scaffolding with Absorb bioresorbable vascular scaffold. Patterns of Pasterkamp remodeling demonstrated at the top panel with a percent of patients in RCT ABSORB II and observational ABSORB B1 trials with a plaque burden (PB) change in ABSORB cohort B1 trial. The bottom panel demonstrates a percentage of the different types of the arterial remodeling in Absorb bioresorbable vascular scaffold patients. The middle dark purple panel shows dynamics of PB in patients of ABSORB cohort B1 trial. Mean PB in subsets failed to achieve Glagovian threshold of a 40% PB in all scenarios. P < 0.05 if compared with XIENCE.