Control of nuclear-cytoplasmic shuttling of Ankrd54 by PKCδ

Figure 5 Schematic of proposed model of PKCδregulation of Ankrd54 nuclear-cytoplasmic shuttling. Model of potential mechanism by which PKCδ regulated the cytoplasmic accumulation of Ankrd54. Ankrd54 shuttles between the nuclear and cytoplasmic compartments, promoted by its NLS and NES motifs. Ankrd54 can interact with Lyn, Btk, Txk, HCLS1, LASP1, Vav1, Hip55 and ESE2L. Nuclear Ankrd54 can localize to PML nuclear bodies and paraspeckles (Para-sp). Lyn, and potentially Btk/Txk, can phosphorylate and activate PKCδ, which can then phosphorylate Ankrd54, promoting cytoplasmic accumulation.