Identification of neuron selective androgen receptor inhibitors

Figure 4 DHT promotes nuclear co-localization of androgen receptor and FOXM1. A: GT1-7 cells expressing a YFP-tagged AR were treated as indicated for 24 h prior to staining with anti-FOXM1 (red) and DAPI (blue); B: Quantification of co-localization using Image J demonstrates significant co-localization of FOXM1 and AR in the presence of DHT and DHT + thiostrepton by both Manders split coefficient and Li’s ICQ value. Error bars represent the mean ± SEM, ^aP < 0.05. AR: Androgen receptor; ICQ: Intensity Correlation Quotient.