Endocrine disrupting chemicals in mixture and obesity, diabetes and related metabolic disorders

doi:10.4331/wjbc.v8.i2.108

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Biol Chem. May 26, 2017; 8(2): 108-119
Published online May 26, 2017. doi: 10.4331/wjbc.v8.i2.108

Table 3 Interactions of some nuclear receptors with endocrine disruptors

Nuclear receptors	Interactions with chemicals
Steroid receptors
ER	BPA (Erα[38], GPR30[104])
AR	BPA[105]
GR	BPA; phthalates[106]
PR	BPA[107]
TR	BPA[108]; brominated flame retardants, BFR[109]
RXR heterodimers
PPARα	Phthalates[110]; polyfluoroalkyl compounds[111]; pyrethrins[112]
PPARγ	Phthalates[110,113]; organotins[76]; BPA[114]
FXR	Pyrethroids[115]
CAR	Phthalates[116,117]
LXRα	Phthalates; BPA[118]
PXR	Phthalates; BPA[119,120]
Other receptors
AhR	Dioxines; PCB dioxin-like[72,121,122]

BPA: Bisphenol A; PCB: Polychlorobiphenyl; ER: Estrogen receptor; AR: Androgen receptor; GR: Glucocorticoid receptor; PR: Progesterone receptor; TR: Thyroid hormone receptor; PPAR: Peroxisome proliferator-activated receptor; FXR: Farnesoid X receptor; CAR: Constitutive androstane receptor; LXR: Liver X receptor; PXR: Pregnane X receptor; AhR: Aryl hydrocarbon receptor.

Citation: Le Magueresse-Battistoni B, Labaronne E, Vidal H, Naville D. Endocrine disrupting chemicals in mixture and obesity, diabetes and related metabolic disorders. World J Biol Chem 2017; 8(2): 108-119
URL: https://www.wjgnet.com/1949-8454/full/v8/i2/108.htm
DOI: https://dx.doi.org/10.4331/wjbc.v8.i2.108