Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host

Figure 22 Schematic representation of polymerization/depolymerization dynamics of microtubules. A: Formation of protofilament with alpha e beta-tubulin heterodimers; B: Formation of microtubule with regions (+) and (-); C:Relationship between polymerization and GTP hydrolysis equilibrium, where is perceived: (1) the polymerization of the GTP-terminal microtubule; (2) an intermediate where the kinetics of hydrolysis and polymerization are equivalent; (3) the microtubule depolymerizing when the hydrolisys rate is superior; and (4) the microtubule salvation mediated by GTP consumption.