Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host

Figure 3 Benznidazole (1) is converted to nitroso metabolites and N-Aryl hydroxylamine, which can be enzymatically reduced to the corresponding 2-aminoimidazole derivative or nitrenio ion, which then is spontaneously di-hydroxylated generating a glyoxal molecule and guanidine derived.