New insights into sodium transport regulation in the distal nephron: Role of G-protein coupled receptors

Figure 3 Signalling pathways trigger by protease-activated receptor 2 activation in the collecting duct. In this segment, protease-activated receptor (PAR) 2 activation increases the NKA activity in the principal cells and the Pds/Na⁺-driven bicarbonate/Cl^- exchanger (NDBCE) system in the B-IC. Both processes involved the activation of the ERK1/2 pathway. CD: Collecting duct; PAR: Protease-activated receptor.