Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence

Figure 5 Genes altered commonly in Ras-/Raf-induced senescence but not in mock cells. A: Genes upregulated commonly, but not in mock cells. There were 259 genes showing > 5-fold upregulation commonly in either of the two RasG12V cells and in either of the two RafV600E cells, but not in mock cells. Genes associated with signal/secreted proteins (P = 1.8 × 10^-10) or extracellular regions (P = 7.0 × 10^-5), e.g., Bmp2, were significantly enriched in these genes; B: Genes downregulated commonly, but not in mock cells. There were 242 genes, e.g., Smad6, showing < 0.2-fold downregulation commonly in either of the two RasG12V cells and in either of the two RafV600E cells, but not in mock cells. Genes associated with signal/secreted protein (P = 2.3 × 10^-17) or extracellular region (P = 1.3 × 10^-17) were significantly enriched, e.g., Cxcl5.