Copyright
©The Author(s) 2016.
World J Biol Chem. Feb 26, 2016; 7(1): 178-187
Published online Feb 26, 2016. doi: 10.4331/wjbc.v7.i1.178
Published online Feb 26, 2016. doi: 10.4331/wjbc.v7.i1.178
Figure 7 Schematic model of homocysteine-mediated apolipoprotein E gene downregulation.
Homocysteine downregulates apoE expression via MEK1/2 activation, IKKβ and p65/50 subunits of NF-κB. NF-κB: Nuclear factor kappa B; apoE: Apolipoprotein E; IKKβ: IκB kinase β.
- Citation: Trusca VG, Mihai AD, Fuior EV, Fenyo IM, Gafencu AV. High levels of homocysteine downregulate apolipoprotein E expression via nuclear factor kappa B. World J Biol Chem 2016; 7(1): 178-187
- URL: https://www.wjgnet.com/1949-8454/full/v7/i1/178.htm
- DOI: https://dx.doi.org/10.4331/wjbc.v7.i1.178