Arctic ground squirrel neuronal progenitor cells resist oxygen and glucose deprivation-induced death

Figure 4 Arctic ground squirrel neuronal progenitor cells proliferate in response to injury faster than other cell lineages. AGS NPCs at 14 d in vitro deprived of oxygen or oxygen and glucose for 48 h followed by 24 h of reoxygenation or reperfusion (modeled by return of oxygen and glucose). The proportion of dividing NPCs (TUJ1+ and Ki67+/Ki67+) (A) increased because the number of dividing NPCs (TUJ1+ and Ki67+) did not change while the number of dividing cells (Ki67+) decreased (B). Horizontal lines P < 0.05; ^aP < 0.05 compared to control; ANOVA followed by a Holm-Sidak test. Mean ± SD. Only differences relative to control are shown. OGD: Oxygen glucose deprivation; NPCs: Neuronal progenitor cells; AGS: Arctic ground squirrel.