API2-MALT1 oncoprotein promotes lymphomagenesis via unique program of substrate ubiquitination and proteolysis

Figure 1 Schematic illustration of the API2-mucosa-associated lymphoid tissue 1 fusion oncoprotein. The most commonly occurring API2-MALT1 fusion is depicted. Recurrent breakpoint positions for both MALT1 and API2 are indicated by arrowheads. The most common breakpoint for API2, by far, is indicated by 1 (approximately 93%). There are two relatively common breakpoints for MALT1, both indicated by asterisks (approximately 42% and 32%, respectively). CARD: Caspase recruitment domain; DD: Death domain; Ig: Immunoglobulin-like; BIR: Baculovirus inhibitor of apoptosis repeat; UBA: Ubiquitin-associated domain; RING: Really interesting new gene; MALT: Mucosa-associated lymphoid tissue.