Regulation of RNA binding proteins in trypanosomatid protozoan parasites

doi:10.4331/wjbc.v7.i1.146

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World J Biol Chem. Feb 26, 2016; 7(1): 146-157
Published online Feb 26, 2016. doi: 10.4331/wjbc.v7.i1.146

Table 3 RNA-binding proteins and mRNA metabolism-related proteins with identified posttranslational modifications in trypanosomes

RBP	T. brucei	T. cruzi	Posttranslational modification
PUF domain
PUF1	Tb927.10.4430	TcCLB.397937.10/TcCLB.508625.160	Phosphorylated in T. brucei[68] Phosphorylated in T. cruzi[71]
PUF2	Tb927.10.12660	TcCLB.507831.110	Phosphorylated in T. brucei[66,68] Phosphorylated in T. cruzi[69]
PUF3	Tb927.10.310	TcCLB.508787.30/TcCLB.468005.9	Phosphorylated in T. brucei[66,68]
PUF4	Tb927.6.820	TcCLB.509399.190/TcCLB.510073.30	Phosphorylated in T. brucei[66,68]
PUF6	Tb927.10.15870	TcCLB.510125.10	Phosphorylated in T. brucei[66,68] Phosphorylated in T. cruzi[71] Sumoylated in T. cruzi[73]
PUF7	Tb927.11.14960	TcCLB.508445.99/TcCLB.511715.100	Sumoylated in T. cruzi[73]
PUF9	Tb927.1.2600	TcCLB.506563.10/TcCLB.503869.40	Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75]
PUF10	Tb927.11.6740	TcCLB.506773.130/TcCLB.508799.70	Arginine-methylated in T. brucei[75]
PUF11	Tb927.11.10810	TcCLB.503757.30/TcCLB.503719.39	Phosphorylated in T. brucei[68]
PUF11	Tb927.11.10810	TcCLB.503757.30/TcCLB.503719.39	Arginine-methylated in T. brucei[75]
RRM domain
PABP1	Tb927.9.9290	TcCLB.506885.70	Phosphorylated in T. brucei[68]
PABP1	Tb927.9.9290	TcCLB.506885.70	Phosphorylated in T. cruzi[70,71] Sumoylated in T. cruzi[73]
PABP2	Tb927.9.10770	TcCLB.508461.140	Phosphorylated in T. brucei[68]
UBP1	Tb927.11.500	TcCLB.507093.220	Phosphorylated in T. cruzi[84]
RBP3	Tb927.11.530	TcCLB.507093.250	Phosphorylated in T. brucei[68]
RBP8	Tb927.7.320	TcCLB.504165.20/TcCLB.508981.20	Phosphorylated in T. brucei[68]
RBP9	Tb927.11.12120	TcCLB.511127.10/TcCLB.511481.70	Phosphorylated in T. brucei[68]
RBP10	Tb927.8.2780	TcCLB.508989.30/TcCLB.509569.120	Phosphorylated in T. brucei[66,68]
RBP12	Tb927.10.12740	TcCLB.511277.200	Phosphorylated in T. brucei[68] Phosphorylated in T. cruzi[71]
U1 snRNP (RBP24)	Tb927.8.4830	TcCLB.508837.140/TcCLB.511383.30	Phosphorylated in T. brucei[68]
RBP28	Tb927.3.1030	TcCLB.511871.110/TcCLB.511863.20	Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75]
RBP29	Tb927.10.13720	TcCLB.511277.580	Phosphorylated in T. cruzi[69,71]
RBP30	Tb927.5.1750	TcCLB.505229.20/TcCLB.510823.20	Phosphorylated in T. brucei[68]
RBP33	Tb927.8.990	TcCLB.503733.50/TcCLB.508569.90	Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75]
RBP35	Tb927.9.12360	TcCLB.510741.40	Phosphorylated in T. brucei[68] Phosphorylated in T. cruzi[70]
RBP38	Tb927.11.5850	TcCLB.508641.180/TcCLB.508515.30	Phosphorylated in T. brucei[68]
RBP42	Tb927.6.4440	TcCLB.509167.140	Phosphorylated in T. cruzi[71]
RBSR1	Tb927.9.6870	TcCLB.506625.70	Phosphorylated in T. brucei[68] Phosphorylated in T. cruzi[69]
RBSR4	Tb927.10.3500	TcCLB.510265.40/TcCLB.510311.50	Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75]
DRBD2	Tb927.9.13990	TcCLB.510755.120/TcCLB.508413.50	Phosphorylated in T. cruzi[69]
DRBD5	Tb927.6.3480	TcCLB.469785.40/TcCLB.507025.50	Phosphorylated in T. brucei[68]
DRBD7	Tb927.4.400	TcCLB.507873.30/TcCLB.510689.60	Phosphorylated in T. brucei[68]
DRBD10	Tb927.11.16020	TcCLB.507037.20/TcCLB.508707.80	Phosphorylated in T. brucei[68]
DRBD11	Tb927.3.3940	TcCLB.503683.30/TcCLB.509999.120	Phosphorylated in T. brucei[68]
DRBD13	Tb927.8.6650	TcCLB.506399.40/TcCLB.509243.20	Phosphorylated in T. brucei[68]
DRBD17	Tb927.8.710	TcCLB.507649.100/TcCLB.508567.100	Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75]
DRBD18	Tb927.11.14090	TcCLB.511727.190	Arginine-methylated in T. brucei[75]
HNRNPH	Tb927.2.3880	TcCLB.511109.130/TcCLB.504157.10	Phosphorylated in T. brucei[68] Phosphorylated in T. cruzi[70,71] Sumoylated in T. cruzi[73]
TRRM1	Tb927.2.4710	TcCLB.509317.60/TcCLB.511621.50	Phosphorylated in T. brucei[66,68] Phosphorylated in T. cruzi[69] Sumoylated in T. cruzi[73]
TRRM3	Tb927.3.3670	TcCLB.506989.100/TcCLB.510149.140	Arginine-methylated in T. brucei[75]
PPCTI	Tb927.5.3750	TcCLB.503619.20/TcCLB.511647.40	Phosphorylated in T. brucei[68]
MRD1	Tb927.8.4170	TcCLB.509561.110/TcCLB.503897.90	Phosphorylated in T. brucei[68]
TSR1	Tb927.8.900	TcCLB.509607.30/TcCLB.503715.10	Phosphorylated in T. brucei[68]
NRBD1/2 (P34/P37)	Tb927.11.14000/Tb927.11.14020	TcCLB.511727.270/TcCLB.511727.290	Arginine methylated in T. brucei[75]
Conserved	Tb927.10.7030	TcCLB.506779.100/TcCLB.511153.100	Arginine-methylated in T. brucei[75]
Conserved	Tb927.11.7310	TcCLB.506779.100/TcCLB.511153.100	Arginine-methylated in T. brucei[75]
Conserved	Tb927.11.14090	TcCLB.511727.190	Arginine-methylated in T. brucei[75]
Conserved	Tb927.11.6240	TcCLB.506297.230/TcCLB.510101.80	Arginine-methylated in T. brucei[75]
Zinc finger domains
ZFP1	Tb927.6.3490	TcCLB.511511.6	Phosphorylated in T. brucei[66,68]
ZFP3	Tb927.3.720	TcCLB.509719.69/TcCLB.509231.39	Phosphorylated in T. brucei[68]
ZC3H5	Tb927.3.740	TcCLB.511867.10/TcCLB.507775.10	Phosphorylated in T. brucei[68]
ZC3H7	Tb927.3.1340	TcCLB.509233.210	Phosphorylated in T. brucei[68]
ZC3H8	Tb927.3.5250	TcCLB.510143.120/TcCLB.508409.310	Phosphorylated in T. brucei[68]
ZC3H8	Tb927.3.5250	TcCLB.510143.120/TcCLB.508409.310	Arginine-methylated in T. brucei[75]
ZC3H11	Tb927.5.810	TcCLB.507305.40	Phosphorylated in T. brucei[68,85]
ZC3H12	Tb927.5.1570	TcCLB.510819.119/TcCLB.506739.99	Phosphorylated in T. brucei[86]
ZC3H13	Tb927.5.1580	No homologue	Phosphorylated in T. brucei[66,68]
ZC3H17	Tb927.7.930	TcCLB.508879.10/TcCLB.508215.10	Phosphorylated in T. brucei[68]
ZC3H18	Tb927.7.2140	TcCLB.511807.160	Phosphorylated in T. brucei[68]
ZC3H20	Tb927.7.2660	TcCLB.503567.9/TcCLB.506859.204	Phosphorylated in T. brucei[68]
ZC3H21	Tb927.7.2670	TcCLB.506859.230/TcCLB.511817.10	Phosphorylated in T. brucei[68]
ZC3H22	Tb927.7.2680	TcCLB.506859.240/TcCLB.511817.20	Phosphorylated in T. brucei[68]
ZC3H23	Tb927.7.4980	TcCLB.509149.20/TcCLB.508175.350	Phosphorylated in T. brucei[68]
ZC3H28	Tb927.9.9450	TcCLB.506885.200/TcCLB.510729.220	Phosphorylated in T. brucei[68] Phosphorylated in T. cruzi[70]
ZC3H29	Tb927.9.9520	TcCLB.510729.210/TcCLB.506885.204	Phosphorylated in T. brucei[68]
ZC3H30	Tb927.10.1540	TcCLB.506977.110	Phosphorylated in T. brucei[68]
ZC3H31	Tb927.10.5150	TcCLB.506009.10/TcCLB.510295.59	Sumoylated in T. cruzi[73]
ZC3H32	Tb927.10.5250	TcCLB.503795.10 /TcCLB.506679.10	Phosphorylated in T. brucei[68]
ZC3H34	Tb927.10.12330	TcCLB.507787.140/TcCLB.507625.70	Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75]
ZC3H35	Tb927.10.12740	TcCLB.511263.30/TcCLB.507831.40	Phosphorylated in T. brucei[68]
ZC3H37/38	Tb927.10.12780	TcCLB.507831.20/TcCLB.511267.20/ TcCLB.511263.50	Phosphorylated in T. brucei[68]
ZC3H39	Tb927.10.14930	TcCLB.508895.50	Phosphorylated in T. brucei[68]
ZC3H40	Tb927.10.14950	TcCLB.508895.60/TcCLB.506211.60	Phosphorylated in T. brucei[66,68] Phosphorylated in T. cruzi[69,71]
ZC3H41	Tb927.11.1980	TcCLB.508355.330/TcCLB.508357.9	Phosphorylated in T. brucei[68]
ZC3H43	Tb927.11.7450	TcCLB.511151.20/TcCLB.508241.90	Phosphorylated in T. brucei[68]
ZC3H44	Tb927.11.7890	TcCLB.506933.50	Phosphorylated in T. brucei[68]
ZC3H46	Tb927.11.16550	TcCLB.507089.30/TcCLB.504085.70	Phosphorylated in T. brucei[68]
ZC3H47	Tb927.6.4960	TcCLB.506945.210	Phosphorylated in T. brucei[68] Phosphorylated in T. cruzi[69]
Conserved	Tb927.11.3970	TcCLB.509229.90/TcCLB.506733.140	Phosphorylated in T. brucei[68]
Conserved	Tb927.9.14120	TcCLB.510759.100/TcCLB.506999.120	Arginine-methylated in T. brucei[75]
Other
NOP44/46	Tb927.8.760	TcCLB.510859.17/TcCLB.510859.10	Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75]
SMD2	Tb927.2.5850	TcCLB.508667.49/TcCLB.511189.80	Phosphorylated in T. brucei[68]
DCL2	Tb927.3.1230	No homologue	Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75]
CAF1	Tb927.6.600	TcCLB.511827.60/TcCLB.510535.60	Phosphorylated in T. brucei[68]
Not1	Tb927.10.1510	TcCLB.509247.30	Phosphorylated in T. cruzi[70]
XRNA	Tb927.7.4900	TcCLB.507817.80	Phosphorylated in T. cruzi[69]
ALBA3	Tb927.4.2040	TcCLB.510877.40	Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75]
ALBA4	Tb927.4.2030	TcCLB.510877.30	Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75]
eIF4E	Tb927.11.11770	TcCLB.508827.30	Phosphorylated in T. brucei[68] Phosphorylated in T. cruzi[70]
	Tb927.6.1870	TcCLB.509037.40/TcCLB.421959.10	Phosphorylated inT. brucei[68]
eIF4G2	Tb927.9.5460	TcCLB.508277.340/TcCLB.506445.20	Phosphorylated in T. brucei[68]
	Tb927.11.10560	TcCLB.510285.100/TcCLB.504827.130	Phosphorylated in T. brucei[68]
eIF4G5	Tb927.8.4500	TcCLB.508989.90	Phosphorylated in T. brucei[68]

RBP: RNA-binding protein; RRM: RNA-recognition motif.

Citation: Romaniuk MA, Cervini G, Cassola A. Regulation of RNA binding proteins in trypanosomatid protozoan parasites. World J Biol Chem 2016; 7(1): 146-157
URL: https://www.wjgnet.com/1949-8454/full/v7/i1/146.htm
DOI: https://dx.doi.org/10.4331/wjbc.v7.i1.146