JAK3 inhibitor VI is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M

Figure 4 Structural analysis of janus kinase 3 inhibitor VI binding to the epidermal growth factor receptor T790M. A: JAK3 inhibitor VI (cyan in EGFR WT: top left, red in EGFR T790M/L858R: top right, or yellow in JAK3: bottom left) was modeled into EGFR WT, EGFR T790M/L858R (LRTM), or JAK3. A superimposed image is also shown (bottom right). The dotted lines indicate putative hydrogen bonds; B: Amino acid sequence alignments of EGFRs and JAKs, and BCR-ABL and Aurora kinases. Asterisk indicates the gatekeeper residues. EGFR: Epidermal growth factor receptor; JAK: Janus kinase; WT: Wild type.