JAK3 inhibitor VI is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M

Figure 3 Janus kinase 3 inhibitor VI suppresses proliferation of NCI-H1975 cells. A, B: NCI-H1975 (A) or A431 (B) cells were treated with JAK3 inhibitor VI, JAK inhibitor I, or gefitinib. Effects of indicated concentration of kinase inhibitors on cell proliferation were analyzed using the MTT assay; C: Effects of JAK3 inhibitor VI on proliferation were compared between NCI-H1975 and A549 cells using the MTT assay. Error bars indicate S.E.M. (n = at least 3); ^aP < 0.05. NS: Not significant; JAK3: Janus kinase 3; MTT: 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide.