Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function

Figure 2 Caldecrin expression and protein structure. A: Caldecrin expression was analyzed by Northern blot. 18S, 28S: 18S, 28S ribosomal RNA; B: Domain structures of caldecrin. Black box: signal peptide; orange box: pro-peptide; blue box: mature protein; red line: disulfide bridges with cysteine number; the H (histidine), D (aspartic acid), S (serine) catalytic triad; C: Ribbon diagram of the crystal structure of human caldecrin (adapted from PDB ID: 4H4F, prepared from [16]). Red line: Disulfide bridge; Yellow line: Pro-peptide; Arrow: β-sheet structure; Cylinder: α-helix structure.