Regulation of MYC gene expression by aberrant Wnt/β-catenin signaling in colorectal cancer

Figure 3 Model for the chromatin interaction network at the MYC gene locus in colorectal cancer cells with elevated nuclear β-catenin. β-Catenin “hijacks” MYC WREs in CRC cells, therefore, driving or stabilizing a distinct promoter-enhancer interaction network that is required for deregulated MYC gene expression. TCF/Lef and β-catenin are depicted as brown and purple ovals, respectively. WRE: Wnt responsive DNA element; CRC: Colorectal cancer; TCF/Lef: T-cell factor/Lymphoid enhancer factor.