Disruption of NAD+ binding site in glyceraldehyde 3-phosphate dehydrogenase affects its intranuclear interactions

doi:10.4331/wjbc.v6.i4.366

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World Journal of Biological Chemistry

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1949-8454

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World J Biol Chem. Nov 26, 2015; 6(4): 366-378
Published online Nov 26, 2015. doi: 10.4331/wjbc.v6.i4.366

Table 1 Mutations introduced to glyceraldehyde 3-phosphate dehydrogenase cDNA ORF

GAPDH variant	Mutagenic primers¹	Nucleotide change	Codon change
Y94A	CGATGCTGGCGCTGAGGCCGTCGTGGAGTCCACTGG	280-281	UAC- > GCC
Y94A	CCAGTGGACTCCACGACGGCCTCAGCGCCAGCATCG	280-281	UAC- > GCC
S98A	GAGTACGTCGTGGAGGCCACTGGCGTCTTCACC	290	UCC- > GCC
S98A	GGTGAAGACGCCAGTGGCCTCCACGACGTACTC	290	UCC- > GCC
T99A	AGTACGTCGTGGAGTCCGCTGGCGTCTTCACCACC	295	ACU- > GCU
T99A	GGTGGTGAAGACGCCAGCGGACTCCACGACGTACT	295	ACU- > GCU
T99I	GAGTACGTCGTGGAGTCCATTGGCGTCTTCA	296	ACU- > AUU
T99I	TGAAGACGCCAATGGACTCCACGACGTACTC	296	ACU- > AUU

¹Mutated nucleotides are indicated in bold font; GAPDH: Glyceraldehyde 3-phosphate dehydrogenase.

Citation: Phadke M, Krynetskaia N, Mishra A, Barrero C, Merali S, Gothe SA, Krynetskiy E. Disruption of NAD⁺ binding site in glyceraldehyde 3-phosphate dehydrogenase affects its intranuclear interactions. World J Biol Chem 2015; 6(4): 366-378
URL: https://www.wjgnet.com/1949-8454/full/v6/i4/366.htm
DOI: https://dx.doi.org/10.4331/wjbc.v6.i4.366