Multifunctional facets of retrovirus integrase

Figure 8 Active site within prototype foamy virus intasome in apo (A) and Raltegravir-bound state (B). Orange spheres indicate Mg²⁺. Active sites residues are labeled. Only the terminal 3’ adenosine (marked A1) is displayed in its chemical form to show the displacement upon RAL binding. The diketo acid group of Raltegravir (RAL) interacts with the metal ions. Adenine is π-stacked against the RAL metal-chelating scaffold. The halobenzoyl group of RAL is marked red. The figures were constructed from PDB entries 3L2R and 3OYA, respectively, in Molsoft ICM-Browser.