Is erythroferrone finally the long sought-after systemic erythroid regulator of iron?

Figure 2 Two potential actions of erythroferrone. After blood loss, stress erythropoiesis is triggered by erythropoietin. This results in erythroferrone release from erythroblasts and in turn down-regulation of hepcidin. As a result, iron absorption and hemoglobin synthesis and erythropoiesis are increased (left). In response to feeding and exercise, myonectin (erythroferrone) produced by myotubes triggers fatty acid uptake by adipocytes and hepatocytes (right). Considering the function of erythroferrone in erythropoiesis, regulation of myoglobin is suggested to be a likely consequence of myonectin release (far right).